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Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations

Fehér, Kristoffer D ; Nakataki, Masahito ; Morishima, Yosuke

Frontiers in human neuroscience, 2017-09, Vol.11, p.471-471 [Periódico revisado por pares]

Switzerland: Frontiers Research Foundation

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  • Título:
    Phase-Dependent Modulation of Signal Transmission in Cortical Networks through tACS-Induced Neural Oscillations
  • Autor: Fehér, Kristoffer D ; Nakataki, Masahito ; Morishima, Yosuke
  • Assuntos: Cortex (motor) ; EEG ; effective connectivity ; Electroencephalography ; Feasibility studies ; functional connectivity ; Magnetic fields ; Neural networks ; Neuroscience ; Prefrontal cortex ; theta oscillations ; Theta rhythms ; transcranial alternating current stimulation ; Transcranial magnetic stimulation
  • É parte de: Frontiers in human neuroscience, 2017-09, Vol.11, p.471-471
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Edited by: Stephane Perrey, Université de Montpellier, France
    Reviewed by: Muthuraman Muthuraman, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Germany; Filippo Brighina, University of Palermo, Italy
  • Descrição: Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online modulatory mechanisms of transcranial alternating current stimulation (tACS)-induced neural oscillations are confined to the primary motor cortex. To address the causal role of oscillatory activity in modulating cortico-cortical signal transmission, we have established a new method using concurrent tACS, transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Through tACS, we introduced 6-Hz (theta) oscillatory activity in the human dorsolateral prefrontal cortex (DLPFC). During tACS, we applied single-pulse TMS over the DLPFC at different phases of tACS and assessed propagation of TMS-induced neural activity with EEG. We show that tACS-induced theta oscillations modulate the propagation of TMS-induced activity in a phase-dependent manner and that phase-dependent modulation is not simply explained by the instantaneous amplitude of tACS. The results demonstrate a phase-dependent modulatory mechanism of tACS at a cortical network level, which is consistent with a causal role of neural oscillations in regulating the efficacy of signal transmission in the brain.
  • Editor: Switzerland: Frontiers Research Foundation
  • Idioma: Inglês
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