Language:

Neural correlates of successful semantic processing during propofol sedation

Adapa, Ram M. ; Davis, Matthew H. ; Stamatakis, Emmanuel A. ; Absalom, Anthony R. ; Menon, David K.

Human brain mapping, 2014-07, Vol.35 (7), p.2935-2949 [Peer Reviewed Journal]

New York, NY: Blackwell Publishing Ltd

Full text available

Citations Cited by

Actions
1. Add to e-Shelf
2. Remove from e-Shelf
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Neural correlates of successful semantic processing during propofol sedation
Author: Adapa, Ram M. ; Davis, Matthew H. ; Stamatakis, Emmanuel A. ; Absalom, Anthony R. ; Menon, David K.
Subjects: Acoustic Stimulation ; Adult ; Analysis of Variance ; Biological and medical sciences ; Brain - blood supply ; Brain - drug effects ; Brain Mapping ; Decision Making - drug effects ; Female ; functional MRI ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypnotics and Sedatives - blood ; Hypnotics and Sedatives - pharmacology ; Image Processing, Computer-Assisted ; inferior frontal gyrus ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Oxygen - blood ; Perception ; propofol ; Propofol - blood ; Propofol - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Reaction Time - drug effects ; sedation ; semantic processing ; Semantics ; Statistics as Topic ; Vision ; Vocabulary ; Young Adult
Is Part Of: Human brain mapping, 2014-07, Vol.35 (7), p.2935-2949
Notes: Raymond and Beverly Sackler Studentship, the Stephen Erskine Fellowship
istex:2D8C5C124AAD69F625D282586CA05F399BD8A09D
ark:/67375/WNG-MX0HZ4N7-Q
ArticleID:HBM22375
British Oxygen Professorship of the Royal College of Anaesthetists
Wellcome Trust - No. 083660/Z/07/Z
Queens' College Cambridge, the UK Medical Research Council funding of the Cognition and Brain Sciences Unit (MC_US_A060_0038)
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Sedation has a graded effect on brain responses to auditory stimuli: perceptual processing persists at sedation levels that attenuate more complex processing. We used fMRI in healthy volunteers sedated with propofol to assess changes in neural responses to spoken stimuli. Volunteers were scanned awake, sedated, and during recovery, while making perceptual or semantic decisions about nonspeech sounds or spoken words respectively. Sedation caused increased error rates and response times, and differentially affected responses to words in the left inferior frontal gyrus (LIFG) and the left inferior temporal gyrus (LITG). Activity in LIFG regions putatively associated with semantic processing, was significantly reduced by sedation despite sedated volunteers continuing to make accurate semantic decisions. Instead, LITG activity was preserved for words greater than nonspeech sounds and may therefore be associated with persistent semantic processing during the deepest levels of sedation. These results suggest functionally distinct contributions of frontal and temporal regions to semantic decision making. These results have implications for functional imaging studies of language, for understanding mechanisms of impaired speech comprehension in postoperative patients with residual levels of anesthetic, and may contribute to the development of frameworks against which EEG based monitors could be calibrated to detect awareness under anesthesia. Hum Brain Mapp 35:2935–2949, 2014. © 2013 Wiley Periodicals, Inc.
Publisher: New York, NY: Blackwell Publishing Ltd
Language: English

Links

Back to results list

Previous Result 9 Next Go to Next page

Implemented by: Social Network Logos:

Neural correlates of successful semantic processing during propofol sedation

Adapa, Ram M. ; Davis, Matthew H. ; Stamatakis, Emmanuel A. ; Absalom, Anthony R. ; Menon, David K.

New York, NY: Blackwell Publishing Ltd

Searching Remote Databases, Please Wait