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Antimutagenic effect of curcumin and its effect on the immune response in mice

Šmerák, Petr ; Polívková, Zdeňka ; Šestáková, Helena ; Štětina, Rudolf ; Bárta, Ivo ; Langová, Martina ; Turek, Bohumil ; Bártová, Jiřina

Czech Journal of Food Sciences, 2006-01, Vol.24 (2), p.72-83 [Periódico revisado por pares]

Prague: Czech Academy of Agricultural Sciences (CAAS)

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Título:
Antimutagenic effect of curcumin and its effect on the immune response in mice
Autor: Šmerák, Petr ; Polívková, Zdeňka ; Šestáková, Helena ; Štětina, Rudolf ; Bárta, Ivo ; Langová, Martina ; Turek, Bohumil ; Bártová, Jiřina
Assuntos: Aflatoxin B1 ; Aflatoxins ; Ames test ; antimutagenic effects ; Bioassays ; blastic transformation tests ; Chemiluminescence ; Comet assay ; Curcumin ; Diet ; Genetic transformation ; Immune response ; Immune system ; Immunomodulation ; Immunosuppression ; In vivo methods and tests ; Inflammation ; micronucleus test ; Mutagenicity ; Mutagens ; Quinoline ; response of immune ; Toxicity
É parte de: Czech Journal of Food Sciences, 2006-01, Vol.24 (2), p.72-83
Descrição: A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.
Editor: Prague: Czech Academy of Agricultural Sciences (CAAS)
Idioma: Inglês;Tcheco;Eslovaco

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Antimutagenic effect of curcumin and its effect on the immune response in mice

Šmerák, Petr ; Polívková, Zdeňka ; Šestáková, Helena ; Štětina, Rudolf ; Bárta, Ivo ; Langová, Martina ; Turek, Bohumil ; Bártová, Jiřina

Prague: Czech Academy of Agricultural Sciences (CAAS)

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