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Ornithine Aspartate and Vitamin-E Combination Has Beneficial Effects on Cardiovascular Risk Factors in an Animal Model of Nonalcoholic Fatty Liver Disease in Rats

de Freitas, Laura Bainy Rodrigues ; Longo, Larisse ; Filippi-Chiela, Eduardo ; de Souza, Valessa Emanoele Gabriel ; Behrens, Luiza ; Pereira, Matheus Henrique Mariano ; Leonhard, Luiza Cecília ; Zanettini, Giulianna ; Pinzon, Carlos Eduardo ; Luchese, Eduardo ; Lima, Guilherme Jorge Semmelmann Pereira ; Cerski, Carlos Thadeu ; Uribe-Cruz, Carolina ; Álvares-da-Silva, Mário Reis

Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (12), p.1773 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Ornithine Aspartate and Vitamin-E Combination Has Beneficial Effects on Cardiovascular Risk Factors in an Animal Model of Nonalcoholic Fatty Liver Disease in Rats
Autor: de Freitas, Laura Bainy Rodrigues ; Longo, Larisse ; Filippi-Chiela, Eduardo ; de Souza, Valessa Emanoele Gabriel ; Behrens, Luiza ; Pereira, Matheus Henrique Mariano ; Leonhard, Luiza Cecília ; Zanettini, Giulianna ; Pinzon, Carlos Eduardo ; Luchese, Eduardo ; Lima, Guilherme Jorge Semmelmann Pereira ; Cerski, Carlos Thadeu ; Uribe-Cruz, Carolina ; Álvares-da-Silva, Mário Reis
Assuntos: animal model ; Animal models ; Animals ; Aspartate ; Cardiomyocytes ; Cardiovascular diseases ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - metabolism ; cardiovascular risk ; Cholesterol ; Collagen ; Dipeptides - therapeutic use ; Disease Models, Animal ; Drug dosages ; Drug Therapy, Combination ; Dyslipidemia ; E-selectin ; Experiments ; Fatty liver ; Fibrosis ; Gene expression ; High fat diet ; IL-1β ; Inflammation ; Intercellular adhesion molecule 1 ; Interleukin 6 ; Lipid metabolism ; Liver - metabolism ; Liver diseases ; Metabolism ; MicroRNAs ; MicroRNAs - metabolism ; Monocyte chemoattractant protein 1 ; Non-alcoholic Fatty Liver Disease - complications ; nonalcoholic fatty liver disease ; Nutrient deficiency ; Ornithine ; ornithine aspartate ; Paracrine signalling ; Physiological aspects ; Ratios ; Rats ; Rats, Sprague-Dawley ; Risk Factors ; steatohepatitis ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Vitamin E ; Vitamin E - therapeutic use ; Vitamins
É parte de: Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (12), p.1773
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
Descrição: Cardiovascular (CV) disease is the main cause of death in nonalcoholic fatty liver disease (NAFLD), a clinical condition without any approved pharmacological therapy. Thus, we investigated the effects of ornithine aspartate (LOLA) and/or Vitamin E (VitE) on CV parameters in a steatohepatitis experimental model. Adult Sprague Dawley rats were randomly assigned (10 animals each) and treated from 16 to 28 weeks with gavage as follows: controls (standard diet plus distilled water (DW)), NAFLD (high-fat choline-deficient diet (HFCD) plus DW), NAFLD+LOLA (HFCD plus LOLA (200 mg/kg/day)), NAFLD+VitE (HFCD plus VitE (150 mg twice a week)) or NAFLD+LOLA+VitE in the same doses. Atherogenic ratios were higher in NAFLD when compared with NAFLD+LOLA+VitE and controls ( < 0.05). Serum concentration of IL-1β, IL-6, TNF-α, MCP-1, e-selectin, ICAM-1, and PAI-1 were not different in intervention groups and controls ( > 0.05). NAFLD+LOLA decreased miR-122, miR-33a, and miR-186 ( < 0.05, for all) in relation to NAFLD. NAFLD+LOLA+VitE decreased miR-122, miR-33a and miR-186, and increased miR-126 ( < 0.05, for all) in comparison to NAFLD and NAFLD+VitE. NAFLD+LOLA and NAFLD+LOLA+VitE prevented liver collagen deposition ( = 0.006) in comparison to NAFLD. Normal cardiac fibers (size and shape) were lower in NAFLD in relation to the others; and the inverse was reported for the percentage of regular hypertrophic cardiomyocytes. NAFLD+LOLA+VitE promoted a significant improvement in atherogenic dyslipidemia, liver fibrosis, and paracrine signaling of lipid metabolism and endothelial dysfunction. This association should be further explored in the treatment of NAFLD-associated CV risk factors.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Ornithine Aspartate and Vitamin-E Combination Has Beneficial Effects on Cardiovascular Risk Factors in an Animal Model of Nonalcoholic Fatty Liver Disease in Rats

Switzerland: MDPI AG

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