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Lessons from KEEPS: the Kronos Early Estrogen Prevention Study

Miller, V. M. ; Taylor, H. S. ; Naftolin, F. ; Manson, J. E. ; Gleason, C. E. ; Brinton, E. A. ; Kling, J. M. ; Cedars, M. I. ; Dowling, N. M. ; Kantarci, K. ; Harman, S. M.

Climacteric : the journal of the International Menopause Society, 2021-04, Vol.24 (2), p.139-145 [Periódico revisado por pares]

England: Taylor & Francis

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  • Título:
    Lessons from KEEPS: the Kronos Early Estrogen Prevention Study
  • Autor: Miller, V. M. ; Taylor, H. S. ; Naftolin, F. ; Manson, J. E. ; Gleason, C. E. ; Brinton, E. A. ; Kling, J. M. ; Cedars, M. I. ; Dowling, N. M. ; Kantarci, K. ; Harman, S. M.
  • Assuntos: Administration, Cutaneous ; Administration, Oral ; Cardiovascular Diseases - prevention & control ; Carotid Intima-Media Thickness ; Conjugated equine estrogens ; Coronary Vessels - drug effects ; Double-Blind Method ; estradiol ; Estradiol - administration & dosage ; Estrogen Replacement Therapy - methods ; Estrogens ; Estrogens - administration & dosage ; Estrogens, Conjugated (USP) - administration & dosage ; Female ; Hormone replacement therapy ; hormone treatments ; Humans ; Menopause ; Menopause - drug effects ; Metabolism ; Middle Aged ; Progesterone - administration & dosage ; Treatment Outcome
  • É parte de: Climacteric : the journal of the International Menopause Society, 2021-04, Vol.24 (2), p.139-145
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    ObjectType-News-3
    content type line 23
    Albert Einstein College of Medicine: Genevieve Neal-Perry, Ruth Freeman, Hussein Amin; Brigham and Women’s Hospital/Harvard Medical School: JoAnn Manson, Maria Bueche, Marie Gerhard-Herman, Kate Kalan, Jan Lieson, Kathryn M. Rexrode, Barbara Richmond, Frank Rybicki, Brian Walsh; Columbia College of Physicians and Surgeons: Rogerio Lobo, Luz Sanabria, Maria Soto, Michelle P. Warren, Ralf C. Zimmerman; Kronos Longevity Research Institute: S. Mitchell Harman, Mary Dunn, Panayiotis D.Tsitouras, Viola Zepeda; Mayo Clinic: Virginia M. Miller, Philip A. Araoz, Rebecca Beck, Dalene Bott-Kitslaar, Sharon L. Mulvagh, Lynne T. Shuster, Teresa G. Zais (deceased); University of California, Los Angeles, CAC Reading Center: Matthew Budoff, Chris Dailing, Yanlin Gao, Angel Solano; University of California, San Francisco: Marcelle Cedars, Nancy Jancar, Grechen Good; Statistical Reading Center: Lisa Palermo; University of Southern California, Atherosclerosis Research Unit/Core Imaging and Reading Center: Howard Hodis/Yanjie Li; University of Utah School of Medicine: Eliot Brinton, Paul N. Hopkins, M. Nazeem Nanjee, Kirtly Jones, Timothy Beals, Stacey Larrinaga-Shum; VA Puget Sound Health Care System and University of Washington School of Medicine: George Merriam (deceased), Pamela Asberry, SueAnn Brickle, Colleen Carney, Molly Carr, Monica Kletke, Lynna C. Smith; Yale University, School of Medicine: Hugh Taylor, Kathryn Czarkowski, Lubna Pal, Linda MacDonald, Mary Jane Minkin, Diane Wall; Others: Frederick Naftolin, Nanette Santoro.
    KEEPS Clinical Centers and Staff
  • Descrição: The Kronos Early Estrogen Prevention Study (KEEPS) was a randomized, double-blind, placebo-controlled trial designed to determine the effects of hormone treatments (menopausal hormone treatments [MHTs]) on the progression of carotid intima-medial thickness (CIMT) in recently menopausal women. Participants less than 3 years from menopause and without a history of overt cardiovascular disease (CVD), defined as no clinical CVD events and coronary artery calcium < 50 Agatston units, received either oral conjugated equine estrogens (0.45 mg/day) or transdermal 17β-estradiol (50 µg/day), both with progesterone (200 mg/day for 12 days/month), or placebo pills and patches for 4 years. Although MHT did not decrease the age-related increase in CIMT, KEEPS provided other important insights about MHT effects. Both MHTs versus placebo reduced the severity of menopausal symptoms and maintained bone density, but differed in efficacy regarding mood/anxiety, sleep, sexual function, and deposition of β-amyloid in the brain. Additionally, genetic variants in enzymes for metabolism and uptake of estrogen affected the efficacy of MHT for some aspects of symptom relief. KEEPS provides important information for use of MHT in clinical practice, including type, dose, and mode of delivery of MHT recently after menopause, and how genetic variants in hormone metabolism may affect MHT efficacy on specific outcomes.
  • Editor: England: Taylor & Francis
  • Idioma: Inglês
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