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Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection

Boriskin, Yury S ; Pécheur, Eve-Isabelle ; Polyak, Stephen J

Virology journal, 2006-07, Vol.3 (1), p.56-56, Article 56 [Peer Reviewed Journal]

England: BioMed Central Ltd

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Title:
Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection
Author: Boriskin, Yury S ; Pécheur, Eve-Isabelle ; Polyak, Stephen J
Subjects: Acute Disease ; Antiviral Agents - pharmacology ; Biochemistry, Molecular Biology ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - virology ; Cell Line, Tumor ; Cell Survival - drug effects ; Hepacivirus - physiology ; Hepatitis C - drug therapy ; Hepatitis C - genetics ; Hepatitis C - metabolism ; Hepatitis C - prevention & control ; Hepatitis C - virology ; Hepatitis C virus ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - genetics ; Hepatitis C, Chronic - metabolism ; Hepatitis C, Chronic - virology ; Humans ; Indoles - pharmacology ; Interferon-beta - genetics ; Interferon-beta - metabolism ; Life Sciences ; Membrane Fusion - drug effects ; Microbial Viability - drug effects ; Receptors, Retinoic Acid - metabolism ; RNA, Viral - biosynthesis ; RNA, Viral - genetics ; Signal Transduction - drug effects ; Virus Replication - drug effects
Is Part Of: Virology journal, 2006-07, Vol.3 (1), p.56-56, Article 56
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Arbidol (ARB) is an antiviral compound that was originally proven effective for treatment of influenza and several other respiratory viral infections. The broad spectrum of ARB anti-viral activity led us to evaluate its effect on hepatitis C virus (HCV) infection and replication in cell culture. Long-term ARB treatment of Huh7 cells chronically replicating a genomic length genotype 1b replicon resulted in sustained reduction of viral RNA and protein expression, and eventually cured HCV infected cells. Pre-treatment of human hepatoma Huh7.5.1 cells with 15 microM ARB for 24 to 48 hours inhibited acute infection with JFH-1 virus by up to 1000-fold. The inhibitory effect of ARB on HCV was not due to generalized cytotoxicity, nor to augmentation of IFN antiviral signaling pathways, but involved impaired virus-mediated membrane fusion. ARB's affinity for membranes may inhibit several aspects of the HCV lifecycle that are membrane-dependent.
Publisher: England: BioMed Central Ltd
Language: English

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Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection

Boriskin, Yury S ; Pécheur, Eve-Isabelle ; Polyak, Stephen J

England: BioMed Central Ltd

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