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Perinatal exposure to an aromatase inhibitor glyphosate-base herbicide reduced male and female social behavior in juvenile age and the sexual behavior at adult female rat

Esther Lopes Ricci Miriam Oliveira Ribeiro; André Rinaldi Fukushima; Thaísa Meira Sandini; Paulo Ricardo Dell’Armelina Rocha; Paula Andrea Faria Waziry Waziry; Maria Martha Bernardi; Helenice de Souza Spinosa

Brazilian Journal of Veterinary Research and Animal Science São Paulo v. 59, p. 1-13, e186467, 2022

São Paulo 2022

Localização: FMVZ - Fac. Med. Vet. e Zootecnia    (SPI - 297 )(Acessar)

  • Título:
    Perinatal exposure to an aromatase inhibitor glyphosate-base herbicide reduced male and female social behavior in juvenile age and the sexual behavior at adult female rat
  • Autor: Esther Lopes Ricci
  • Miriam Oliveira Ribeiro; André Rinaldi Fukushima; Thaísa Meira Sandini; Paulo Ricardo Dell’Armelina Rocha; Paula Andrea Faria Waziry Waziry; Maria Martha Bernardi; Helenice de Souza Spinosa
  • Assuntos: COMPORTAMENTO ANIMAL; HERBICIDAS; PERÍODO PERINATAL -- VETERINÁRIA; Dimorfismo Sexual; Inibidor De Aromatase; Herbicide; Sexual Dimorphism; Social Behavior; Perinatal Treatment; Aromatase Inhibitor
  • É parte de: Brazilian Journal of Veterinary Research and Animal Science São Paulo v. 59, p. 1-13, e186467, 2022
  • Notas: Disponível em: https://doi.org/10.11606/issn.1678-4456.bjvras.2022.186467. Acesso em: 7 jul. 2022
  • Notas Locais: Na FMVZ, ver acervo: SPI-297 Documento Digital
  • Descrição: Objectives: The herbicide glyphosate, a pesticide used in agriculture to control weeds, both in food crops and in other agricultural areas, has been identified as an endocrine modulator through the inhibition of aromatase activity and the activation of estrogen receptors. The present study examined the effects of a glyphosate-based herbicide (Roundup® (GLY-BH) on sexual dimorphism of rats after perinatal exposure to low and high GLY-BH in males and females offspring. Methods: Two groups of pregnant rats were treated with two doses of GLY-BH (50 or 150 mg/kg) from day 15 of gestation (GD15) to postnatal day 7 (PND7). Play fighting behavior was observed at the juvenile stage and during social and sexual behaviors in adulthood. Results: Perinatal GLY-BH exposure reduced male and female body weight at 28, 75, and 90 days of age. The play fighting behavior was decreased in both sexes, but female rats were more affected. The sexual behaviors were reduced only in females. Conclusions: Perinatal exposure to both doses of GLY-BH promoted sexually dimorphic effects in both juvenile and adulthood stages. These effects were attributed to the inhibition of aromatase activity induced by exposure to GLY-BH in the perinatal period
  • Editor: São Paulo
  • Data de criação/publicação: 2022
  • Formato: p. 1-13.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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