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Protective Effect of Neutral Electrolyzed Saline on Gentamicin-Induced Nephrotoxicity: Evaluation of Histopathologic Parameters in a Murine Model

Aurelien-Cabezas, Nomely S ; Paz-Michel, Brenda A ; Jacinto-Cortes, Ivan ; Delgado-Enciso, Osiris G ; Montes-Galindo, Daniel A ; Cabrera-Licona, Ariana ; Zaizar-Fregoso, Sergio A ; Paz-Garcia, Juan ; Ceja-Espiritu, Gabriel ; Melnikov, Valery ; Guzman-Esquivel, Jose ; Rodriguez-Sanchez, Iram P ; Martinez-Fierro, Margarita L ; Delgado-Enciso, Ivan

Medicina (Kaunas, Lithuania), 2023-02, Vol.59 (2), p.397 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Protective Effect of Neutral Electrolyzed Saline on Gentamicin-Induced Nephrotoxicity: Evaluation of Histopathologic Parameters in a Murine Model
Autor: Aurelien-Cabezas, Nomely S ; Paz-Michel, Brenda A ; Jacinto-Cortes, Ivan ; Delgado-Enciso, Osiris G ; Montes-Galindo, Daniel A ; Cabrera-Licona, Ariana ; Zaizar-Fregoso, Sergio A ; Paz-Garcia, Juan ; Ceja-Espiritu, Gabriel ; Melnikov, Valery ; Guzman-Esquivel, Jose ; Rodriguez-Sanchez, Iram P ; Martinez-Fierro, Margarita L ; Delgado-Enciso, Ivan
Assuntos: Animals ; anti-inflammatory agents ; Care and treatment ; Chemical properties ; Chlorine ; Complications and side effects ; Creatinine ; Disease Models, Animal ; Drug dosages ; Electrolysis ; Fibrosis ; Gentamicin ; Gentamicins - metabolism ; Gentamicins - pharmacology ; Health aspects ; Hydrogen ; hypochlorous acid ; kidney ; Kidney - pathology ; Kidney diseases ; Kidneys ; Laboratory animals ; Male ; Mice ; Oxidative Stress ; Physiologic salines ; Prospective Studies ; Rats ; Rats, Wistar ; reactive oxygen species ; Saline Solution - pharmacology ; Single-Blind Method ; Testing ; toxicity
É parte de: Medicina (Kaunas, Lithuania), 2023-02, Vol.59 (2), p.397
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: : Gentamicin (GM) is a nephrotoxic aminoglycoside. Neutral electrolyzed saline (SES) is a compound with anti-inflammatory, antioxidant, and immunomodulatory properties. The objective of the present study was to evaluate whether kidney damage by GM can be prevented and/or reversed through the administration of SES. : The study was carried out as a prospective, single-blind, five-arm, parallel-group, randomized, preclinical trial. The nephrotoxicity model was established in male BALB/c mice by administering GM at a dose of 100 mg/kg/day intraperitoneally for 30 days, concomitantly administering (+) SES or placebo (physiologic saline solution), and then administering SES for another 30 days after the initial 30 days of GM plus SES or placebo. At the end of the test, the mice were euthanized, and renal tissues were evaluated histopathologically. : The GM + placebo group showed significant tubular injury, interstitial fibrosis, and increased interstitial infiltrate of inflammatory cells compared with the group without GM. Tubular injury and interstitial fibrosis were lower in the groups that received concomitant GM + SES compared with the GM + placebo group. SES administration for 30 days after the GM administration periods (GM + placebo and GM + SES for 30 days) did not reduce nephrotoxicity. : Intraperitoneal administration of SES prevents gentamicin-induced histologic nephrotoxicity when administered concomitantly, but it cannot reverse the damage when administered later.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Protective Effect of Neutral Electrolyzed Saline on Gentamicin-Induced Nephrotoxicity: Evaluation of Histopathologic Parameters in a Murine Model

Switzerland: MDPI AG

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