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Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients

Abdalla, DS ; Monteiro, HP ; Oliveira, JA ; Bechara, EJ

Clinical chemistry (Baltimore, Md.), 1986-05, Vol.32 (5), p.805-807 [Periódico revisado por pares]

England: Am Assoc Clin Chem

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Título:
Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients
Autor: Abdalla, DS ; Monteiro, HP ; Oliveira, JA ; Bechara, EJ
Assuntos: Adult ; Aged ; Antipsychotic Agents - therapeutic use ; Bipolar Disorder - blood ; Bipolar Disorder - drug therapy ; Bipolar Disorder - enzymology ; Erythrocytes - enzymology ; Female ; Glutathione Peroxidase - blood ; Humans ; Lithium - therapeutic use ; Male ; Middle Aged ; Schizophrenia - blood ; Schizophrenia - enzymology ; Superoxide Dismutase - blood
É parte de: Clinical chemistry (Baltimore, Md.), 1986-05, Vol.32 (5), p.805-807
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
Descrição: Activities of superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) in erythrocytes were evaluated in 50 schizophrenic and 20 manic-depressive patients, who were or were not being treated with different neuroleptic drugs, and results were compared with those for 58 normal individuals. Neuroleptic-treated and untreated schizophrenic patients showed similar activities of superoxide dismutase, about 60% higher than those found in normal individuals (p less than 0.001). In manic-depressive patients treated with either lithium (n = 8) or lithium plus neuroleptic drugs (n = 12), superoxide dismutase activities were increased by about 40% over those of normal subjects (p less than 0.001). Significantly abnormal activities of glutathione peroxidase were found only in the sub-group of schizophrenic women. These results are interpreted in terms of active oxygen species involvement in the psychiatric manifestations.
Editor: England: Am Assoc Clin Chem
Idioma: Inglês

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Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients

Abdalla, DS ; Monteiro, HP ; Oliveira, JA ; Bechara, EJ

England: Am Assoc Clin Chem

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