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Senescent stroma promotes prostate cancer progression: The role of miR-210

Taddei, Maria Letizia ; Cavallini, Lorenzo ; Comito, Giuseppina ; Giannoni, Elisa ; Folini, Marco ; Marini, Alberto ; Gandellini, Paolo ; Morandi, Andrea ; Pintus, Gianfranco ; Raspollini, Maria Rosaria ; Zaffaroni, Nadia ; Chiarugi, Paola

Molecular oncology, 2014-12, Vol.8 (8), p.1729-1746 [Periódico revisado por pares]

United States: Elsevier B.V

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Título:
Senescent stroma promotes prostate cancer progression: The role of miR-210
Autor: Taddei, Maria Letizia ; Cavallini, Lorenzo ; Comito, Giuseppina ; Giannoni, Elisa ; Folini, Marco ; Marini, Alberto ; Gandellini, Paolo ; Morandi, Andrea ; Pintus, Gianfranco ; Raspollini, Maria Rosaria ; Zaffaroni, Nadia ; Chiarugi, Paola
Assuntos: Angiogenesis ; Bone marrow ; Cell culture ; Cell Line ; Cell Line, Tumor ; Cell proliferation ; Cells, Cultured ; Deoxyribonucleic acid ; Disease Progression ; DNA ; DNA damage ; Endothelial cells ; Fibroblasts ; Genotype & phenotype ; Humans ; Hypoxia ; Immunoglobulins ; Immunohistochemistry ; Macrophages ; Male ; Mesenchyme ; Metabolites ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miR-210 ; Monocytes ; Morphogenesis ; Potassium ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Senescence ; Stroma ; Tumor microenvironment
É parte de: Molecular oncology, 2014-12, Vol.8 (8), p.1729-1746
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia-induced miR-210 in young fibroblasts increases their senescence-associated features and converts them into cancer associated fibroblast (CAF)-like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages. •Hypoxic senescent fibroblasts deeply sustain prostate cancer progression and modify tumor microenvironment.•Senescent fibroblasts share a common gene expression profile with activated fibroblasts.•miR-210 activates fibroblasts and induces cell senescence, thus sustaining prostate cancer invasiveness.
Editor: United States: Elsevier B.V
Idioma: Inglês

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Senescent stroma promotes prostate cancer progression: The role of miR-210

Taddei, Maria Letizia ; Cavallini, Lorenzo ; Comito, Giuseppina ; Giannoni, Elisa ; Folini, Marco ; Marini, Alberto ; Gandellini, Paolo ; Morandi, Andrea ; Pintus, Gianfranco ; Raspollini, Maria Rosaria ; Zaffaroni, Nadia ; Chiarugi, Paola

United States: Elsevier B.V

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