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Creating a False Memory in the Hippocampus

Ramirez, Steve ; Liu, Xu ; Lin, Pei-Ann ; Suh, Junghyup ; Pignatelli, Michele ; Redondo, Roger L. ; Ryan, Tomás J. ; Tonegawa, Susumu

Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6144), p.387-391 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Creating a False Memory in the Hippocampus
Autor: Ramirez, Steve ; Liu, Xu ; Lin, Pei-Ann ; Suh, Junghyup ; Pignatelli, Michele ; Redondo, Roger L. ; Ryan, Tomás J. ; Tonegawa, Susumu
Assuntos: Activation ; Amygdala ; Amygdala - physiology ; Anatomical correlates of behavior ; Animals ; Association ; Associative memory ; Behavioral neuroscience ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; CA1 Region, Hippocampal - cytology ; CA1 Region, Hippocampal - physiology ; Channelrhodopsins ; Conditioning ; Conditioning (Psychology) ; Control groups ; Dentate Gyrus - cytology ; Dentate Gyrus - physiology ; Dependovirus - genetics ; Doxycycline - administration & dosage ; Experimental Groups ; False memory ; Fear ; Formations ; Freezing ; Fundamental and applied biological sciences. Psychology ; Genes, fos ; Hippocampus ; Human ; Light ; Memory ; Memory - physiology ; Mental Recall - physiology ; Mental stimulation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons ; Neurons - physiology ; Neurosciences ; Optogenetics ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Recall ; Stimuli ; Vertebrates: nervous system and sense organs
É parte de: Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6144), p.387-391
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SourceType-Scholarly Journals-1
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Descrição: Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram—bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Creating a False Memory in the Hippocampus

Ramirez, Steve ; Liu, Xu ; Lin, Pei-Ann ; Suh, Junghyup ; Pignatelli, Michele ; Redondo, Roger L. ; Ryan, Tomás J. ; Tonegawa, Susumu

Washington, DC: American Association for the Advancement of Science

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