Idioma:

MicroRNA-mediated downregulation of mTOR FGFR3 controls tumor growth induced by Src-related oncogenic pathways

ONEYAMA, C ; IKEDA, J ; OKUZAKI, D ; SUZUKI, K ; KANOU, T ; SHINTANI, Y ; MORII, E ; OKUMURA, M ; AOZASA, K ; OKADA, M

Oncogene, 2011-08, Vol.30 (32), p.3489-3501 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
MicroRNA-mediated downregulation of mTOR FGFR3 controls tumor growth induced by Src-related oncogenic pathways
Autor: ONEYAMA, C ; IKEDA, J ; OKUZAKI, D ; SUZUKI, K ; KANOU, T ; SHINTANI, Y ; MORII, E ; OKUMURA, M ; AOZASA, K ; OKADA, M
Assuntos: Animals ; Biological and medical sciences ; Cell Line ; Cell physiology ; Cell Proliferation - drug effects ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cell Transformation, Neoplastic - genetics ; Cells, Cultured ; Cluster Analysis ; Down-Regulation ; Epidermal growth factor ; Fibroblast growth factor receptor 3 ; Fibroblast growth factor receptors ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Genes ; Genetic aspects ; Growth ; Growth factors ; HEK293 Cells ; Humans ; Immunoblotting ; Immunohistochemistry ; Kinases ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; MAP kinase ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Molecular and cellular biology ; Molecular modelling ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Physiological aspects ; Protein-tyrosine kinase ; Pyrimidines - pharmacology ; Rapamycin ; Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 3 - genetics ; Receptor, Fibroblast Growth Factor, Type 3 - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleic acid ; RNA ; RNA Interference ; Signal Transduction - drug effects ; Signal Transduction - genetics ; Src protein ; src-Family Kinases - genetics ; src-Family Kinases - metabolism ; TOR protein ; TOR Serine-Threonine Kinases - genetics ; TOR Serine-Threonine Kinases - metabolism ; Transformed cells ; Tumorigenicity ; Tumors
É parte de: Oncogene, 2011-08, Vol.30 (32), p.3489-3501
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The tyrosine kinase c-Src is upregulated in various human cancers, but the molecular mechanisms underlying c-Src-mediated tumor growth remain unclear. Here we examined the involvement of microRNAs in the c-Src-mediated tumor growth. Microarray profiling revealed that c-Src activation downregulates a limited set of microRNAs, including miR-99a, which targets oncogenic mammalian target of rapamycin (mTOR) and fibroblast growth factor receptor 3 (FGFR3). Re-expression of miR-99a suppressed tumor growth of c-Src-transformed cells, and this effect was restored by the overexpression of mTOR. The downregulation of miR-99a was also observed in epidermal growth factor- and Ras-transformed cells, and it was suppressed by inhibiting the mitogen-activated protein kinase (MAPK) pathway. Furthermore, miR-99a downregulation is associated with mTOR/FGFR3 upregulation in various human lung cancer cells/tissues. The tumorigenicity of these cells was suppressed by the introduction of miR-99a. These findings suggest that the miR-99a-mTOR/FGFR3 pathway is crucial for controlling tumor growth in a wide range of human cancers that harbor upregulation of the Src-related oncogenic pathways.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

MicroRNA-mediated downregulation of mTOR FGFR3 controls tumor growth induced by Src-related oncogenic pathways

ONEYAMA, C ; IKEDA, J ; OKUZAKI, D ; SUZUKI, K ; KANOU, T ; SHINTANI, Y ; MORII, E ; OKUMURA, M ; AOZASA, K ; OKADA, M

Basingstoke: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.