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Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan

Demizu, Yusuke ; Mizumoto, Masashi ; Onoe, Tsuyoshi ; Nakamura, Naoki ; Kikuchi, Yasuhiro ; Shibata, Tetsushi ; Okimoto, Tomoaki ; Sakurai, Hideyuki ; Akimoto, Tetsuo ; Ono, Kota ; Daimon, Takashi ; Murayama, Shigeyuki

Cancer science, 2017-05, Vol.108 (5), p.972-977 [Periódico revisado por pares]

England: John Wiley & Sons, Inc

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Título:
Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan
Autor: Demizu, Yusuke ; Mizumoto, Masashi ; Onoe, Tsuyoshi ; Nakamura, Naoki ; Kikuchi, Yasuhiro ; Shibata, Tetsushi ; Okimoto, Tomoaki ; Sakurai, Hideyuki ; Akimoto, Tetsuo ; Ono, Kota ; Daimon, Takashi ; Murayama, Shigeyuki
Assuntos: Bone cancer ; Bone Neoplasms - pathology ; Bone Neoplasms - radiotherapy ; Bone tumors ; Cancer therapies ; Charged particles ; Chondrosarcoma ; Disease-Free Survival ; Female ; Fractions ; Hospitals ; Humans ; Japan ; Male ; Metastases ; Middle Aged ; Multicenter study ; Multivariate analysis ; NMR ; Nuclear magnetic resonance ; Original ; Osteosarcoma ; Patients ; Planning ; proton beam therapy ; Proton Therapy - methods ; R&D ; Radiation therapy ; Radiotherapy Dosage ; Research & development ; Retrospective Studies ; Sacrum ; sarcoma ; Sarcoma - pathology ; Sarcoma - radiotherapy ; Skull ; skull base ; Skull Base - pathology ; Skull Base - radiation effects ; Spinal cord ; spine ; Spine - pathology ; Spine - radiation effects ; Studies ; Survival ; Tomography ; Tumors ; Variables
É parte de: Cancer science, 2017-05, Vol.108 (5), p.972-977
Notas: Funding information
Japan Agency for Medical Research and Development, Practical Research for Innovative Cancer Control(15ck0106034 h0102), Translational Research Network Program (C33)
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Descrição: We conducted a retrospective, nationwide multicenter study to evaluate the clinical outcomes of proton beam therapy for bone sarcomas of the skull base and spine in Japan. Eligibility criteria included: (i) histologically proven bone sarcomas of the skull base or spine; (ii) no metastases; (iii) ≥20 years of age; and (iv) no prior treatment with radiotherapy. Of the 103 patients treated between January 2004 and January 2012, we retrospectively analyzed data from 96 patients who were followed‐up for >6 months or had died within 6 months. Seventy‐two patients (75.0%) had chordoma, 20 patients (20.8%) had chondrosarcoma, and four patients (7.2%) had osteosarcoma. The most frequent tumor locations included the skull base in 68 patients (70.8%) and the sacral spine in 13 patients (13.5%). Patients received a median total dose of 70.0 Gy (relative biological effectiveness). The median follow‐up was 52.6 (range, 6.3–131.9) months. The 5‐year overall survival, progression‐free survival, and local control rates were 75.3%, 49.6%, and 71.1%, respectively. Performance status was a significant factor for overall survival and progression‐free survival, whilst sex was a significant factor for local control. Acute Grade 3 and late toxicities of ≥Grade 3 were observed in nine patients (9.4%) each (late Grade 4 toxicities [n = 3 patients; 3.1%]). No treatment‐related deaths occurred. Proton beam therapy is safe and effective for the treatment of bone sarcomas of the skull base and spine in Japan. However, larger prospective studies with a longer follow‐up are warranted. This study is the first to demonstrate the safety and efficacy of proton beam therapy for bone sarcomas of the skull base and spine on a nationwide multicenter basis in Japan. Univariate and multivariate analyses revealed that performance status is a significant factor for overall survival and progression‐free survival, and sex is a significant factor for local control.
Editor: England: John Wiley & Sons, Inc
Idioma: Inglês

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Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan

Demizu, Yusuke ; Mizumoto, Masashi ; Onoe, Tsuyoshi ; Nakamura, Naoki ; Kikuchi, Yasuhiro ; Shibata, Tetsushi ; Okimoto, Tomoaki ; Sakurai, Hideyuki ; Akimoto, Tetsuo ; Ono, Kota ; Daimon, Takashi ; Murayama, Shigeyuki

England: John Wiley & Sons, Inc

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