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The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

Zanatta, Alysson ; Rocha, André M. ; Carvalho, Filomena M. ; Pereira, Ricardo M. A. ; Taylor, Hugh S. ; Motta, Eduardo L. A. ; Baracat, Edmund C. ; Serafini, Paulo C.

Journal of assisted reproduction and genetics, 2010-12, Vol.27 (12), p.701-710 [Periódico revisado por pares]

Boston: Springer US

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Título:
The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review
Autor: Zanatta, Alysson ; Rocha, André M. ; Carvalho, Filomena M. ; Pereira, Ricardo M. A. ; Taylor, Hugh S. ; Motta, Eduardo L. A. ; Baracat, Edmund C. ; Serafini, Paulo C.
Assuntos: Adult ; Assisted Reproduction Technologies ; Embryo Implantation ; Endometriosis ; Endometriosis - etiology ; Endometriosis - genetics ; Endometrium ; Endometrium - metabolism ; Estrogens - metabolism ; Etiology ; Female ; Gene Expression Regulation, Developmental ; Genes ; Genes, Homeobox ; Gynecology ; Homeobox A10 Proteins ; Homeodomain Proteins - adverse effects ; Homeodomain Proteins - genetics ; Human Genetics ; Humans ; Infertility ; Infertility, Female - etiology ; Infertility, Female - genetics ; Medicine ; Medicine & Public Health ; Menstruation ; Pelvis ; Pregnancy ; Progesterone - metabolism ; Reproductive Medicine ; Transcription Factors - genetics ; Womens health
É parte de: Journal of assisted reproduction and genetics, 2010-12, Vol.27 (12), p.701-710
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Purpose Endometriosis and its associated infertility have been the object of continuous research for over a century. To understand the molecular mechanisms underlying the disease, it has become necessary to determine the aspects of its etiology that are not explained by the retrograde menstruation theory. This could in turn elucidate how various clinical and surgical treatments might affect the evolution and remission of the disease. Methods This review is focused on the most recent clinical and laboratory findings regarding the association of HOXA10 with endometriosis and infertility. Result The homebox (Hox/HOX) proteins are highly conserved transcription factors that determine segmental body identities in multiple species, including humans. Hoxa10/HOXA10 is directly involved in the embryogenesis of the uterus and embryo implantation via regulation of downstream genes. Cyclical endometrial expression of Hoxa10/HOXA10, with a peak of expression occurring during the window of implantation, is observed in the adult in response to estrogen and progesterone. Women with endometriosis do not demonstrate the expected mid-luteal rise of HOXA10 expression, which might partially explain the infertility observed in many of these patients. Recent studies also demonstrated HOXA10 expression in endometriotic foci outside the Müllerian tract. Conclusions Multiple lines of evidence suggest that the actions of the homeobox A10 ( Hoxa10/HOXA10 ) gene could account for some aspects of endometriosis.
Editor: Boston: Springer US
Idioma: Inglês

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The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

Zanatta, Alysson ; Rocha, André M. ; Carvalho, Filomena M. ; Pereira, Ricardo M. A. ; Taylor, Hugh S. ; Motta, Eduardo L. A. ; Baracat, Edmund C. ; Serafini, Paulo C.

Boston: Springer US

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