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Usefulness of telomere length in DNA from human teeth for age estimation

Márquez-Ruiz, Ana Belén ; González-Herrera, Lucas ; Valenzuela, Aurora

International journal of legal medicine, 2018-03, Vol.132 (2), p.353-359 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Usefulness of telomere length in DNA from human teeth for age estimation
Autor: Márquez-Ruiz, Ana Belén ; González-Herrera, Lucas ; Valenzuela, Aurora
Assuntos: Adolescent ; Adult ; Age ; Age Determination by Teeth - methods ; Aged ; Aged, 80 and over ; Aging - genetics ; Cell division ; Chromosomes ; Chronology ; Correlation analysis ; Deoxyribonucleic acid ; DNA ; DNA - isolation & purification ; Female ; Forensic Medicine ; Forensic odontology ; Human remains ; Humans ; Linear Models ; Male ; Medical Law ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Real-Time Polymerase Chain Reaction ; Regression models ; Sex ; Statistical analysis ; Statistical methods ; Teeth ; Telomere - genetics ; Tooth - chemistry ; Yeast ; Young Adult
É parte de: International journal of legal medicine, 2018-03, Vol.132 (2), p.353-359
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Age estimation is widely used to identify individuals in forensic medicine. However, the accuracy of the most commonly used procedures is markedly reduced in adulthood, and these methods cannot be applied in practice when morphological information is limited. Molecular methods for age estimation have been extensively developed in the last few years. The fact that telomeres shorten at each round of cell division has led to the hypothesis that telomere length can be used as a tool to predict age. The present study thus aimed to assess the correlation between telomere length measured in dental DNA and age, and the effect of sex and tooth type on telomere length; a further aim was to propose a statistical regression model to estimate the biological age based on telomere length. DNA was extracted from 91 tooth samples belonging to 77 individuals of both sexes and 15 to 85 years old and was used to determine telomere length by quantitative real-time PCR. Our results suggested that telomere length was not affected by sex and was greater in molar teeth. We found a significant correlation between age and telomere length measured in DNA from teeth. However, the equation proposed to predict age was not accurate enough for forensic age estimation on its own. Age estimation based on telomere length in DNA from tooth samples may be useful as a complementary method which provides an approximate estimate of age, especially when human skeletal remains are the only forensic sample available.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Usefulness of telomere length in DNA from human teeth for age estimation

Márquez-Ruiz, Ana Belén ; González-Herrera, Lucas ; Valenzuela, Aurora

Berlin/Heidelberg: Springer Berlin Heidelberg

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