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Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

Kim, Nayun ; Huang, Shar-yin N. ; Williams, Jessica S. ; Li, Yue C. ; Clark, Alan B. ; Cho, Jang-Eun ; Kunkel, Thomas A. ; Pommier, Yves ; Jinks-Robertson, Sue

Science (American Association for the Advancement of Science), 2011-06, Vol.332 (6037), p.1561-1564 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I
Autor: Kim, Nayun ; Huang, Shar-yin N. ; Williams, Jessica S. ; Li, Yue C. ; Clark, Alan B. ; Cho, Jang-Eun ; Kunkel, Thomas A. ; Pommier, Yves ; Jinks-Robertson, Sue
Assuntos: Amino Acid Transport Systems, Basic - genetics ; Base Sequence ; Biological and medical sciences ; Camptothecin - pharmacology ; Canavanine - pharmacology ; Deoxyribonucleic acid ; DNA ; DNA Breaks ; DNA Topoisomerases, Type I - metabolism ; DNA, Fungal - chemistry ; DNA, Fungal - metabolism ; DNA, Single-Stranded - metabolism ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Genetic mutation ; Microsatellite Repeats ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Mutagenesis ; Mutagenesis. Repair ; Mutation ; Nucleic Acid Conformation ; Nucleic acids ; Product labeling ; Ribonuclease H - genetics ; Ribonuclease H - metabolism ; Ribonucleic acid ; Ribonucleotides ; Ribonucleotides - metabolism ; RNA ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - enzymology ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - genetics ; Sequence Deletion ; Tandem repeat sequences ; Transcription, Genetic ; Yeast ; Yeasts
É parte de: Science (American Association for the Advancement of Science), 2011-06, Vol.332 (6037), p.1561-1564
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The ribonuclease (RNase) H class of enzymes degrades the RNA component of RNA:DNA hybrids and is important in nucleic acid metabolism. RNase H2 is specialized to remove single ribonucleotides [ribonucleoside monophosphates (rNMPs)] from duplex DNA, and its absence in budding yeast has been associated with the accumulation of deletions within short tandem repeats. Here, we demonstrate that rNMP-associated deletion formation requires the activity of Top1, a topoisomerase that relaxes supercoils by reversibly nicking duplex DNA. The reported studies extend the role of Top1 to include the processing of rNMPs in genomic DNA into irreversible single-strand breaks, an activity that can have distinct mutagenic consequences and may be relevant to human disease.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

Kim, Nayun ; Huang, Shar-yin N. ; Williams, Jessica S. ; Li, Yue C. ; Clark, Alan B. ; Cho, Jang-Eun ; Kunkel, Thomas A. ; Pommier, Yves ; Jinks-Robertson, Sue

Washington, DC: American Association for the Advancement of Science

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