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Obesity QTLs on Mouse Chromosomes 2 and 17
Taylor, Benjamin A. ; Phillips, Sandra J.
Genomics (San Diego, Calif.), 1997-08, Vol.43 (3), p.249-257
[Periódico revisado por pares]
San Diego, CA: Elsevier Inc
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Título:
Obesity QTLs on Mouse Chromosomes 2 and 17
Autor:
Taylor, Benjamin A.
;
Phillips, Sandra J.
Assuntos:
Adipose Tissue - metabolism
;
ADIPOSE TISSUES
;
adiposity index
;
Analysis of Variance
;
Animals
;
Biological and medical sciences
;
Blood Glucose - metabolism
;
BODY FAT
;
Body Mass Index
;
Body Weight
;
CARTE GENETIQUE
;
Chromosome Mapping
;
CHROMOSOME MAPS
;
Classical genetics, quantitative genetics, hybrids
;
CROSSBREDS
;
Crosses, Genetic
;
DNA - analysis
;
Female
;
Fundamental and applied biological sciences. Psychology
;
GENETIC INHERITANCE
;
GENETIC MAPPING
;
GENETIC MAPS
;
Genetic Markers - genetics
;
GENETICA
;
GENETICS
;
Genetics of eukaryotes. Biological and molecular evolution
;
Genetics, Population
;
GENETIQUE
;
Genotype
;
HEREDITE
;
HERENCIA GENETICA
;
LOCI
;
LOCUS
;
Lod Score
;
Male
;
MAPAS GENETICOS
;
MICE
;
Mice, Inbred AKR
;
Mice, Inbred C57BL
;
MOLECULAR MAPPING
;
Obesity - genetics
;
obq3 locus
;
obq4 locus
;
OVERWEIGHT
;
PRODUCTOS DEL CRUZAMIENTO
;
PRODUIT DE CROISEMENT
;
Quantitative Trait, Heritable
;
QUANTITATIVE TRAITS
;
RATON
;
Sex Factors
;
SOBREPESO
;
SOURIS
;
STRAINS
;
SURPOIDS
;
TEJIDO ADIPOSO
;
TISSU ADIPEUX
;
Vertebrata
É parte de:
Genomics (San Diego, Calif.), 1997-08, Vol.43 (3), p.249-257
Notas:
S30
9741287
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição:
The inheritance of obesity has been analyzed in an intercross between the mouse strains AKR/J and C57L/J. Two novel obesity quantitative trait loci (QTLs) have been identified using the strategy of selective DNA pooling. One QTL affecting adiposity,Obq3,was mapped to a 39-cM segment near the middle of Chromosome 2, with a peak lod score (5.1) just distal to theD2Mit15locus. The AKR/JObq3allele confers increased adiposity in a nearly additive manner, and males are more affected than females. A second obesity QTL (Obq4) maps to the centromeric end of Chromosome 17, with a lod score peak of 4.6 atD17Mit143.The obesity-conferring allele is contributed by C57L/J and acts in a recessive or an additive manner.Obq4also has more influence in males and affects the inguinal fat depot differentially.Obq3andObq4account for 7.0 and 6.1% of the phenotypic variance in adiposity (gender-merged data), respectively. The possible relationships between these QTLs and previously described obesity QTLs and candidate genes are discussed. The large number of different obesity QTLs that have been described in mice and the relatively small effects contributed by individual loci suggest considerable genetic complexity.
Editor:
San Diego, CA: Elsevier Inc
Idioma:
Inglês
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