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Fusaspirols A-D, novel oxaspirol derivatives isolated from Fusarium solani B-18

Ariefta, Nanang Rudianto ; Nikmawahda, Hasna Tazkia ; Aboshi, Takako ; Murayama, Tetsuya ; Tawaraya, Keitaro ; Koseki, Takuya ; Katagi, Genta ; Kakihara, Yoshito ; Shiono, Yoshihito

Tetrahedron, 2019-03, Vol.75 (10), p.1371-1377 [Periódico revisado por pares]

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Título:
Fusaspirols A-D, novel oxaspirol derivatives isolated from Fusarium solani B-18
Autor: Ariefta, Nanang Rudianto ; Nikmawahda, Hasna Tazkia ; Aboshi, Takako ; Murayama, Tetsuya ; Tawaraya, Keitaro ; Koseki, Takuya ; Katagi, Genta ; Kakihara, Yoshito ; Shiono, Yoshihito
Assuntos: Endophyte ; Fusarium solani ; Fusaspirols ; Oxaspirols
É parte de: Tetrahedron, 2019-03, Vol.75 (10), p.1371-1377
Descrição: Four novel compounds with γ-methylidene-spirobutanolide core, fusaspirols A-D, were isolated from the brown rice culture of Fusarium solani B-18. Their structures were established by extensive spectroscopic analyses of 1D/2D-NMR, HRESITOFMS, and chemical derivatization. The absolute configurations of secondary alcohols in fusaspirols A and D were determined using modified Mosher's ester method. Fusaspirol A and 4,9-di-O-acetylfusaspirol A activated a signaling pathway in osteoclastic differentiation of murine macrophage derived RAW264.7 cells. [Display omitted] •Four novel oxaspirol derivatives were isolated from Fusarium solani B-18.•Their structures were established by extensive spectroscopic analyses of 1D/2D-NMR, HRESITOFMS, and chemical transformation.•All reported compounds were tested for osteoclastic differentiation activity using murine macrophage derived RAW264.7 cells.
Editor: Elsevier Ltd
Idioma: Inglês

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