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Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation

Noori, S ; McNamara, P ; Jain, A ; Lavoie, P M ; Wickremasinghe, A ; Merritt, T A ; Solomon, T ; Sekar, K ; Attridge, J T ; Swanson, J R ; Gillam-Krakauer, M ; Reese, J ; Poindexter, B B ; Brook, M ; Auchus, R J ; Clyman, R I

Journal of perinatology, 2015-02, Vol.35 (2), p.123-127 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
Autor: Noori, S ; McNamara, P ; Jain, A ; Lavoie, P M ; Wickremasinghe, A ; Merritt, T A ; Solomon, T ; Sekar, K ; Attridge, J T ; Swanson, J R ; Gillam-Krakauer, M ; Reese, J ; Poindexter, B B ; Brook, M ; Auchus, R J ; Clyman, R I
Assuntos: Adrenal glands ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - methods ; Cardiotonic Agents - administration & dosage ; Cardiotonic Agents - adverse effects ; Catecholamine ; Catecholamines ; Catecholamines - administration & dosage ; Catecholamines - adverse effects ; Complications and side effects ; Congenital diseases ; Coronary vessels ; Design standards ; Diagnosis ; Dobutamine - administration & dosage ; Dobutamine - adverse effects ; Dopamine ; Dopamine - administration & dosage ; Dopamine - adverse effects ; Drug Resistance ; Ductus Arteriosus, Patent - surgery ; Echocardiography ; Electrocardiography ; Female ; Health aspects ; Hormones ; Humans ; Hypotension ; Hypotension - diagnosis ; Hypotension - drug therapy ; Hypotension - etiology ; Hypotension - physiopathology ; Infant, Newborn ; Infant, Premature ; Infants ; Ligation ; Male ; Patent ductus arteriosus ; Postoperative Complications - diagnosis ; Postoperative Complications - drug therapy ; Postoperative Complications - physiopathology ; Risk factors ; Treatment Outcome ; Ventricle
É parte de: Journal of perinatology, 2015-02, Vol.35 (2), p.123-127
Descrição: We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation. A standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was > 15 μg kg(-1)min(-1). Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension). Forty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration. We speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation

Noori, S ; McNamara, P ; Jain, A ; Lavoie, P M ; Wickremasinghe, A ; Merritt, T A ; Solomon, T ; Sekar, K ; Attridge, J T ; Swanson, J R ; Gillam-Krakauer, M ; Reese, J ; Poindexter, B B ; Brook, M ; Auchus, R J ; Clyman, R I

United States: Nature Publishing Group

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