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Diagnostic Criteria for Primary Immunodeficiencies

Conley, Mary Ellen ; Notarangelo, Luigi D. ; Etzioni, Amos

Clinical immunology (Orlando, Fla.), 1999-12, Vol.93 (3), p.190-197 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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  • Título:
    Diagnostic Criteria for Primary Immunodeficiencies
  • Autor: Conley, Mary Ellen ; Notarangelo, Luigi D. ; Etzioni, Amos
  • Assuntos: Biological and medical sciences ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Medical sciences
  • É parte de: Clinical immunology (Orlando, Fla.), 1999-12, Vol.93 (3), p.190-197
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    ObjectType-Review-3
    content type line 23
  • Descrição: The identification of many genes responsible for primary immunodeficiencies has provided us with a new perspective to evaluate these disorders. It has clarified the clinical and laboratory findings that are most consistently associated with a specific gene, demonstrated the spectrum of clinical severity seen in a particular disorder, and shown that not all of the patients with identical clinical and laboratory findings have mutations in the same gene. This new information allows us to reevaluate the criteria that we use to make diagnoses. The diagnostic criteria are meant to establish simple, objective, and clear guidelines that ensure that different physicians and scientists are using the same definitions when they include patients in research studies. These criteria may also help physicians formulate a diagnosis in patients with abnormalities of the immune system. The diagnostic criteria are divided into three categories: definitive, probable, and possible. To guard against the inclusion of patients who have polymorphic variants in the genes associated with immunodeficiency and to specify the clinical or laboratory finding that is most consistently abnormal in a particular disorder, the patient must fulfill an inclusion criterion that is characteristic of the disorder.
  • Editor: San Diego, CA: Elsevier Inc
  • Idioma: Inglês
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