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Diffuse decreased gray matter in patients with idiopathic craniocervical dystonia: a voxel-based morphometry study

Piccinin, Camila C ; Piovesana, Luiza G ; Santos, Maria C A ; Guimarães, Rachel P ; De Campos, Brunno M ; Rezende, Thiago J R ; Campos, Lidiane S ; Torres, Fabio R ; Amato-Filho, Augusto C ; França, Jr, Marcondes C ; Lopes-Cendes, Iscia ; Cendes, Fernando ; D'Abreu, Anelyssa

Frontiers in neurology, 2015-01, Vol.5, p.283-283 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Diffuse decreased gray matter in patients with idiopathic craniocervical dystonia: a voxel-based morphometry study
  • Autor: Piccinin, Camila C ; Piovesana, Luiza G ; Santos, Maria C A ; Guimarães, Rachel P ; De Campos, Brunno M ; Rezende, Thiago J R ; Campos, Lidiane S ; Torres, Fabio R ; Amato-Filho, Augusto C ; França, Jr, Marcondes C ; Lopes-Cendes, Iscia ; Cendes, Fernando ; D'Abreu, Anelyssa
  • Assuntos: cervical dys ; Craniocervical dystonia ; gray matter ; Neuroimag ; Neuroscience ; segmental dysto ; voxe
  • É parte de: Frontiers in neurology, 2015-01, Vol.5, p.283-283
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Reviewed by: Paolo Calabresi, Santa Maria della Misericordia Hospital, Italy; Francesca Morgante, University of Messina, Italy; Giacomo Koch, Fondazione Santa Lucia IRCCS, Italy; Héctor Alberto González-Usigli, Instituto Mexicano del Seguro Social, Mexico
    This article was submitted to Movement Disorders, a section of the journal Frontiers in Neurology.
    Edited by: Antonio Pisani, Università degli Studi di Roma Tor Vergata, Italy
  • Descrição: Recent studies have addressed the role of structures other than the basal ganglia in the pathophysiology of craniocervical dystonia (CCD). Neuroimaging studies have attempted to identify structural abnormalities in CCD but a clear pattern of alteration has not been established. We performed whole-brain evaluation using voxel-based morphometry (VBM) to identify patterns of gray matter (GM) changes in CCD. We compared 27 patients with CCD matched in age and gender to 54 healthy controls. VBM was used to compare GM volumes. We created a two-sample t-test corrected for subjects' age, and we tested with a level of significance of p < 0.001 and false discovery rate (FDR) correction (p < 0.05). Voxel-based morphometry demonstrated significant reductions of GM using p < 0.001 in the cerebellar vermis IV/V, bilaterally in the superior frontal gyrus, precuneus, anterior cingulate and paracingulate, insular cortex, lingual gyrus, and calcarine fissure; in the left hemisphere in the supplementary motor area, inferior frontal gyrus, inferior parietal gyrus, temporal pole, supramarginal gyrus, rolandic operculum, hippocampus, middle occipital gyrus, cerebellar lobules IV/V, superior, and middle temporal gyri; in the right hemisphere, the middle cingulate and precentral gyrus. Our study did not report any significant result using the FDR correction. We also detected correlations between GM volume and age, disease duration, duration of botulinum toxin treatment, and the Marsden-Fahn dystonia scale scores. We detected large clusters of GM changes chiefly in structures primarily involved in sensorimotor integration, motor planning, visuospatial function, and emotional processing.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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