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The effects of enoxaparin on the reparative processes in experimental osteonecrosis of the femoral head of the rat

Norman, D ; Miller, Y. (Rambam Medical Center, Issrael) ; Sabo, E ; Misselevich, I ; Peskin, B ; Zinman, C ; Levin, D ; Reis, D.N ; Boss, J.H

APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2002-03, Vol.110 (3), p.221-228 [Periódico revisado por pares]

Oxford, UK: Munksgaard International Publishers

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Título:
The effects of enoxaparin on the reparative processes in experimental osteonecrosis of the femoral head of the rat
Autor: Norman, D ; Miller, Y. (Rambam Medical Center, Issrael) ; Sabo, E ; Misselevich, I ; Peskin, B ; Zinman, C ; Levin, D ; Reis, D.N ; Boss, J.H
Assuntos: animal model of human disease ; ANIMAL MODELS ; Animals ; Biological and medical sciences ; BONE DISEASES ; Bone Remodeling - drug effects ; Bones, joints and connective tissue. Antiinflammatory agents ; ENFERMEDADES HUMANAS ; ENFERMEDADES OSEAS ; Enoxaparin ; Enoxaparin - pharmacology ; Enoxaparin - therapeutic use ; Femur Head - drug effects ; Femur Head - pathology ; Fibrinolytic Agents - pharmacology ; Fibrinolytic Agents - therapeutic use ; HEPARIN ; HEPARINA ; HEPARINE ; HUESOS DE LOS MIEMBROS ; HUMAN DISEASES ; Legg-Calvé-Perthes disease ; LIMB BONES ; MALADIE DE L'HOMME ; Male ; Medical sciences ; MODELE ANIMAL ; MODELOS ANIMALES ; OS DES MEMBRES ; osteonecrosis ; Osteonecrosis - drug therapy ; Osteonecrosis - pathology ; OSTEOPATHIE ; Pharmacology. Drug treatments ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; unfractionated heparin and low-molecular-weight heparin
É parte de: APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2002-03, Vol.110 (3), p.221-228
Notas: 2002000697
L74
ArticleID:apm197
istex:21AB153D6FAF614BFC33718117344A4ED4A680ED
ark:/67375/WNG-FHHXSKCN-M
Received March 14, 2001.
Accepted November 1, 2001.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The blood supply of one femoral head of 6‐month‐old rats was severed by incising the periosteum of the neck and cutting the ligamentum teres. The rats were killed on the 30th postoperative day and the femoral bones were obtained for semiquantification of the reparative processes in the necrotic heads. Fourteen rats were treated with enoxaparin and 14 untreated animals served as controls. Statistically, the amounts of necrotic bone in the epiphysis were less, the extent of remodeling of the femoral heads was milder, and the articular cartilage degeneration was slighter in the enoxaparin‐treated than untreated rats. There was no significant difference in the quantities of newly formed bone in femoral heads of treated and untreated rats. These findings are in agreement with the known effects of unfractionated and low‐molecular‐weight heparins which enhance osteoclastic bone resorption and angiogenesis and decrease osteoblastic bone formation. The former activities, operative in minimizing the structural distortion of the femoral head, oppose the crucial event in the pathogenesis of post‐osteonecrotic osteoarthritis.
Editor: Oxford, UK: Munksgaard International Publishers
Idioma: Inglês

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The effects of enoxaparin on the reparative processes in experimental osteonecrosis of the femoral head of the rat

Norman, D ; Miller, Y. (Rambam Medical Center, Issrael) ; Sabo, E ; Misselevich, I ; Peskin, B ; Zinman, C ; Levin, D ; Reis, D.N ; Boss, J.H

Oxford, UK: Munksgaard International Publishers

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