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Relative contribution of vitamin D deficiency to subclinical atherosclerosis in Indian context: Preliminary findings

Mantha, Srinivas ; Tripuraneni, Sudha Lakshmi ; Fleisher, Lee A ; Roizen, Michael F ; Mantha, Venkat Ramana Rao ; Dasari, Prasada Rao

Medicine (Baltimore), 2021-08, Vol.100 (32), p.e26916-e26916 [Periódico revisado por pares]

United States: Lippincott Williams & Wilkins

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  • Título:
    Relative contribution of vitamin D deficiency to subclinical atherosclerosis in Indian context: Preliminary findings
  • Autor: Mantha, Srinivas ; Tripuraneni, Sudha Lakshmi ; Fleisher, Lee A ; Roizen, Michael F ; Mantha, Venkat Ramana Rao ; Dasari, Prasada Rao
  • Assuntos: Adult ; Atherosclerosis - diagnosis ; Atherosclerosis - epidemiology ; Atherosclerosis - etiology ; Biomarkers - blood ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; India - epidemiology ; Male ; Middle Aged ; Observational Study ; Prospective Studies ; Risk Factors ; Ultrasonography - methods ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - epidemiology
  • É parte de: Medicine (Baltimore), 2021-08, Vol.100 (32), p.e26916-e26916
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Asian Indians have a genetic predisposition to atherothrombotic risk. common carotid intima-media thickness (CCIMT) measured by ultrasound is a quantitative marker for atherosclerotic burden and a derived variable, that is, "CCIMT statistical Z-score (Z-score)" is useful for better quantification. The association between vitamin D deficiency and atherosclerosis is inconclusive. Since, vitamin D deficiency is highly prevalent in India, there is a need to study its relative contribution to subclinical atherosclerotic burden.This prospective cross-sectional study (n = 117) in apparently healthy individuals aged 20 to 60 years sought to identify the determinants of CCIMT Z score with CCIMT measured by "echo-tracking" method. A multivariable linear regression analysis was done with CCIMT Z score as dependent variable and the following as independent variables: age, body mass index, waist-to-height ratio, total cholesterol to HDL ratio (TC-HDL ratio), serum vitamin D3 levels (ng/mL), sex, diabetes mellitus, current cigarette smoking status. A diagnostic prediction model was also developed with a threshold value of 1.96 for CCIMT Z score.The mean (SD) for calendar age (y) was 40 (8). There were 26 (22.22%) individuals in sample with CCIMT Z score ≥1.96 (advanced stage) of whom 14 (23.33%) were <40 y (n = 60). The mean score was 1.28 (90th percentile) in the entire sample. Vitamin D3 deficiency with a mean (SD) blood level (ng/mL) of 14.3 (6.4) was noted and prevalence of deficiency was 81%. The final model wasCCIMT Z-score = 0.80 +  (0.841 × current smoking = 1) + (0.156 × TC-HDL ratio) - (0.0263 × vitamin D3 blood level in ng/mL).The decreasing order of association is smoking, TC-HDL ratio, and vitamin D3. With the model, likelihood ratio (95% CIs) was better for positive test 3.5 (1.23-9.94) than that for a negative test 0.83 (0.66-1.02).Internal validation with Bootstrap resampling revealed stability of baseline diagnostic variables.There is substantial subclinical atherosclerotic burden in Indian setting with independent contribution by vitamin D deficiency. The model is valuable in "ruling-in" of the underlying advanced atherosclerosis. The study is limited by convenient sampling and lack of external validation of the model.
  • Editor: United States: Lippincott Williams & Wilkins
  • Idioma: Inglês
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