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Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

Luyt, Charles-Edouard, MD, PhD ; Combes, Alain, MD, PhD ; Becquemin, Marie-Hélène, MD ; Beigelman-Aubry, Catherine, MD ; Hatem, Stéphane, MD, PhD ; Brun, Anne-Laure, MD ; Zraik, Nizar, MD ; Carrat, Fabrice, MD, PhD ; Grenier, Philippe A., MD ; Richard, Jean-Christophe M., MD ; Mercat, Alain, MD ; Brochard, Laurent, MD ; Brun-Buisson, Christian, MD ; Chastre, Jean, MD

Chest, 2012-09, Vol.142 (3), p.583-592 [Periódico revisado por pares]

Northbrook, IL: American College of Chest Physicians

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Título:
Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS
Autor: Luyt, Charles-Edouard, MD, PhD ; Combes, Alain, MD, PhD ; Becquemin, Marie-Hélène, MD ; Beigelman-Aubry, Catherine, MD ; Hatem, Stéphane, MD, PhD ; Brun, Anne-Laure, MD ; Zraik, Nizar, MD ; Carrat, Fabrice, MD, PhD ; Grenier, Philippe A., MD ; Richard, Jean-Christophe M., MD ; Mercat, Alain, MD ; Brochard, Laurent, MD ; Brun-Buisson, Christian, MD ; Chastre, Jean, MD
Assuntos: Adult ; Anxiety - epidemiology ; Anxiety - psychology ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Depression - epidemiology ; Depression - psychology ; France - epidemiology ; Human viral diseases ; Humans ; Incidence ; Infectious diseases ; Influenza A Virus, H1N1 Subtype ; Influenza, Human - complications ; Influenza, Human - epidemiology ; Longitudinal Studies ; Lung - diagnostic imaging ; Lung - physiopathology ; Male ; Medical sciences ; Middle Aged ; Outcome Assessment (Health Care) ; Pandemics ; Pneumology ; Prospective Studies ; Pulmonary/Respiratory ; Quality of Life - psychology ; Registries ; Respiratory Distress Syndrome, Adult - etiology ; Respiratory Distress Syndrome, Adult - psychology ; Respiratory Distress Syndrome, Adult - therapy ; Respiratory Function Tests ; Respiratory Therapy - methods ; Retrospective Studies ; Steroids - therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases
É parte de: Chest, 2012-09, Vol.142 (3), p.583-592
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m2 ) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for posttraumatic stress disorder (41% and 44%). Conclusions One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes. Trial registry ClinicalTrials.gov ; No.: NCT01271842 ; URL: www.clinicaltrials.gov
Editor: Northbrook, IL: American College of Chest Physicians
Idioma: Inglês

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Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

Northbrook, IL: American College of Chest Physicians

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