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Forensic DNA typing biology, technology, and genetics of STR markers

John M. Butler (John Marshall) 1969-

Burlington, MA Elsevier Academic Press c2005

Available at EPELM - Esc. Politécnica-Bib Eng Elet., Mec. e Naval    (577.2 B977f2 ) and other locations(GetIt)

  • Title:
    Forensic DNA typing biology, technology, and genetics of STR markers
  • Author: John M. Butler (John Marshall) 1969-
  • Subjects: DNA fingerprinting; Forensic genetics; DNA -- Synthesis; GENÉTICA; DNA Fingerprinting -- methods; Databases, Nucleic Acid; Forensic Medicine
  • Notes: Includes bibliographical references and indexes
  • Description: Conteúdo: Overview and history of DNA typing -- DNA biology review -- Sample collection, DNA extraction and DNA quantitation -- The polymerase chain reaction (DNA amplification) -- Commonly used short tandem repeat markers and commercial kits -- Biology of STRs : stutter products, non-template addition, microvariants, null alleles, and mutation rates -- Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number -- Single nucleotide polymorphisms and other bi-allelic markers -- Y chromosome DNA testing -- Mitochondrial DNA analysis -- Non-human DNA testing and microbial forensics -- DNA separation methods : slab-gel and capillary electrophoresis -- DNA detection methods : fluorescent dyes and silver-staining -- Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems -- STR genotyping issues -- Laboratory validation -- New technologies, automation, and expert systems -- Combined DNA index system (CODIS) and the use of DNA databases -- Basic genetic principles, statistics, and probability -- STR population database analyses -- Profile frequency estimates, likelihood ratios, and source attribution -- Approaches to statistical analysis of mixtures and degraded DNA -- Kinship and parentage testing -- Mass disaster DNA victim identification.
  • Publisher: Burlington, MA Elsevier Academic Press
  • Creation Date: c2005
  • Format: xvii, 660 p. ill. (some col.) 26 cm.
  • Language: English
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