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Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies

João Renato Rebello Pinho Jorge Alexandre Fares; Isabel Takano Oba; Maria Regina Alves Cardoso; Cláudia Patara Saraceni; Celso Granato

Canadian Journal of Microbiology Ottawa v. 49, n. 8, p. 503-507, 2003

Ottawa 2003

Localização: FSP - Faculdade de Saúde Pública    (HEP-18/2003 )(Acessar)

  • Título:
    Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies
  • Autor: João Renato Rebello Pinho
  • Jorge Alexandre Fares; Isabel Takano Oba; Maria Regina Alves Cardoso; Cláudia Patara Saraceni; Celso Granato
  • Assuntos: HEPATITE C; TERAPIA DE SUBSTITUIÇÃO RENAL; REAÇÃO EM CADEIA POR POLIMERASE; VÍRUS DA HEPATITE C (GENÉTICA)
  • É parte de: Canadian Journal of Microbiology Ottawa v. 49, n. 8, p. 503-507, 2003
  • Descrição: Abstract: The aims of this study were to (i) evaluate the prevalence and the incidence of hepatitis C virus (HCV) infection in hemodialysis patients in two different centers in São Paulo (Brazil), (ii) determine the time required to detect HCV infection among these patients by serology or PCR, (iii) establish the importance of alanine aminotransferase determination as a marker of HCV infection, and (iv) identify the HCV genotypes in this population. Serum samples were collected monthly for 1 year from 281 patients admitted to hospital for hemodialysis. Out of 281 patients, 41 patients (14.6 percent) were HCV positive; six patients seroconverted during this study (incidence=3.1/1000 person-month). In 1.8 percent (5/281) of cases, RNA was detected before the appearance of antibodies (up to 5 months), and in 1.1 percent (3/281) of cases, RNA was the unique marker of HCV infection. The genotypes found were 1a, 1b, 3a, and 4a. The presence of genotype 4a is noteworthy, since it is a rare genotype in Brazil. These data pointed out the high prevalence and incidence of HCV infection at hemodialysis centers in Brazil and showed that routine PCR is fundamental for improving the detection of HCV carriers among patients undergoing hemodialysis
  • Editor: Ottawa
  • Data de criação/publicação: 2003
  • Formato: p. 503-507.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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