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Is Local Nitric Oxide Availability Responsible for Myocardial Salvage after Remote Preconditioning?

Arroyo-Martínez, Esbeidira Aranet ; Meaney, Alejandra ; Gutiérrez-Salmeán, Gabriela ; Rivera-Capello, Juan Miguel ; González-Coronado, Vidal ; Alcocer-Chauvet, Alejandro ; Castillo, Genaro ; Nájera, Nayelli ; Ceballos, Guillermo ; Meaney, Eduardo

Arquivos brasileiros de cardiologia, 2016-08, Vol.107 (2), p.154-162 [Revista revisada por pares]

Brazil: Sociedade Brasileira de Cardiologia - SBC

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Título:
Is Local Nitric Oxide Availability Responsible for Myocardial Salvage after Remote Preconditioning?
Autor: Arroyo-Martínez, Esbeidira Aranet ; Meaney, Alejandra ; Gutiérrez-Salmeán, Gabriela ; Rivera-Capello, Juan Miguel ; González-Coronado, Vidal ; Alcocer-Chauvet, Alejandro ; Castillo, Genaro ; Nájera, Nayelli ; Ceballos, Guillermo ; Meaney, Eduardo
Materias: Aged ; CARDIAC & CARDIOVASCULAR SYSTEMS ; Creatinine - blood ; Electrocardiography - methods ; Female ; Glomerular Filtration Rate ; Humans ; Ischemic Preconditioning, Myocardial - methods ; Isquemia ; Male ; Middle Aged ; Myocardial Infarction - metabolism ; Myocardial Reperfusion Injury - prevention & control ; Nitric Oxide - blood ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type III - metabolism ; Original ; Percutaneous Coronary Intervention ; Precondicionamento Isquêmico Miocárdico ; Reperfusão ; Troponin I - blood ; Óxido Nítrico
Es parte de: Arquivos brasileiros de cardiologia, 2016-08, Vol.107 (2), p.154-162
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descripción: Remote ischemic preconditioning (RIPC) represents an attractive therapy for myocardial protection, particularly when ischemic events can be anticipated. Although several hypothetic mechanisms have been proposed, no definite molecular pathways have been elucidated. We evaluated the effect of brachial circulation cuff occlusion on myocardial ischemic tolerance, necrosis, and nitric oxide (NO) in patients with ischemic heart disease undergoing elective percutaneous coronary interventions (PCI). 46 patients were randomly allocated into two groups: control and RIPC before PCI procedures. Electrocardiographic analysis, serum concentrations of troponin I (cTn-I) were measured at baseline and 24 hours after PCI. A blood sample from the atherosclerotic plaque was drawn to determine nitrate and nitrites. RIPC increased the availability of NO in the stented coronary artery. Control patients presented a small but significant increase in cTn-I, whilst it remained unchanged in preconditioned group. The preconditioning maneuver not only preserved but also enhanced the sum of R waves. RIPC induced an intracoronary increase of NO levels associated with a decrease in myocardial damage (measured as no increase in cTn-I) with electrocardiographic increases in the sum of R waves, suggesting an improved myocardium after elective PCI.
Editor: Brazil: Sociedade Brasileira de Cardiologia - SBC
Idioma: Inglés;Portugués

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Is Local Nitric Oxide Availability Responsible for Myocardial Salvage after Remote Preconditioning?

Arroyo-Martínez, Esbeidira Aranet ; Meaney, Alejandra ; Gutiérrez-Salmeán, Gabriela ; Rivera-Capello, Juan Miguel ; González-Coronado, Vidal ; Alcocer-Chauvet, Alejandro ; Castillo, Genaro ; Nájera, Nayelli ; Ceballos, Guillermo ; Meaney, Eduardo

Brazil: Sociedade Brasileira de Cardiologia - SBC

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