Idioma:

TARGETING A NOVEL DNA-DAMAGE SIGNALING PATHWAY TO TREAT GLIOMAS

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Título:
TARGETING A NOVEL DNA-DAMAGE SIGNALING PATHWAY TO TREAT GLIOMAS
Assuntos: carcinogenesis ; DNA damage ; drug screening ; glioblastoma ; glioma
Notas: http://nla.gov.au/nla.party-593921
http://dx.doi.org/10.13039/501100000925
Descrição: Glioblastoma Multiforme (GBM) is a high grade brain tumour for which current treatment modalities are inadequate. Tumour recurrence is almost inevitable and average life expectancy is measured in months. We have identified two proteins as potential therapeutic targets and demonstrated that depleting these proteins in vitro severely impacts on tumour cell viability. We will investigate the impact of targeting these proteins in mouse models of human gliomas and dissect the mechanism that leads to their upregulation in tumour cells. | $AUD 97,783.53 | Project Grants | New Investigator Grant
Data de criação/publicação: 2014
Idioma: Inglês

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