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EphA2 and EphA3 Maintain Tumour Initiating Cells and are Therapeutic Targets in Brain Cancer

2017

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  • Título:
    EphA2 and EphA3 Maintain Tumour Initiating Cells and are Therapeutic Targets in Brain Cancer
  • Assuntos: Eph receptors ; glioblastoma ; glioma ; microenvironment ; therapeutic antibodies
  • Notas: http://nla.gov.au/nla.party-623462
    http://dx.doi.org/10.13039/501100000925
  • Descrição: High-grade glioma (HGG) is the most common adult brain cancer; current treatments have increased survival times by months only. Our studies have shown brain cancer specific expression of a family of cell surface proteins called Eph receptors. Furthermore we have shown targeting these receptors with Eph antibodies leads to a significant reduction in brain cancer tumour growth. We now propose to test targeting these receptors in combination to achieve greater responses with minimal side effects. | $AUD 612,860.30 | Project Grants | New Investigator Grant
  • Data de criação/publicação: 2017
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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