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TOLERANCE TO ISLET AUTOANTIGENS IN TYPE 1 DIABETES

Bach, Jean-François ; Chatenoud, Lucienne

Annual review of immunology, 2001-01, Vol.19 (1), p.131-161 [Periódico revisado por pares]

Palo Alto, CA 94303-0139: Annual Reviews

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TOLERANCE TO ISLET AUTOANTIGENS IN TYPE 1 DIABETES
Autor: Bach, Jean-François ; Chatenoud, Lucienne
Assuntos: Animals ; Antigen Presentation ; Autoantigens - immunology ; Autoantigens - therapeutic use ; Autoimmune Diseases - immunology ; CD25 antigen ; CD3 ; CD3 antigen ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD62L protein ; Clinical Trials as Topic ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Clonal Anergy ; Clonal Deletion ; Cytokines - physiology ; Desensitization, Immunologic ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - prevention & control ; Diabetes Mellitus, Type 1 - therapy ; GAD ; Genetic Predisposition to Disease ; Humans ; Immune Tolerance ; immunoregulation ; insulin ; Islets of Langerhans - immunology ; Killer Cells, Natural - immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Transgenic ; Muromonab-CD3 - therapeutic use ; Prediabetic State - therapy ; T-Lymphocyte Subsets - immunology ; Th2 ; Th2 Cells - immunology
É parte de: Annual review of immunology, 2001-01, Vol.19 (1), p.131-161
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Descrição: Tolerance to β cell autoantigens represents a fragile equilibrium. Autoreactive T cells specific to these autoantigens are present in most normal individuals but are kept under control by a number of peripheral tolerance mechanisms, among which CD4 + CD25 + CD62L + T cell-mediated regulation probably plays a central role. The equilibrium may be disrupted by inappropriate activation of autoantigen-specific T cells, notably following to local inflammation that enhances the expression of the various molecules contributing to antigen recognition by T cells. Even when T cell activation finally overrides regulation, stimulation of regulatory cells by CD3 antibodies may reset the control of autoimmunity. Other procedures may also lead to disease prevention. These procedures are essentially focused on Th2 cytokines, whether used systemically or produced by Th2 cells after specific stimulation by autoantigens. Protection can also be obtained by NK T cell stimulation. Administration of β cell antigens or CD3 antibodies is now being tested in clinical trials in prediabetics and/or recently diagnosed diabetes.
Editor: Palo Alto, CA 94303-0139: Annual Reviews
Idioma: Inglês

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TOLERANCE TO ISLET AUTOANTIGENS IN TYPE 1 DIABETES

Bach, Jean-François ; Chatenoud, Lucienne

Palo Alto, CA 94303-0139: Annual Reviews

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