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Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR

Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer

Molecular plant, 2010 (1), p.236-245 [Periódico revisado por pares]

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  • Título:
    Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR
  • Autor: Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer
  • Assuntos: 分子动力学模型 ; 分布式结构 ; 域名系统 ; 植物细胞 ; 浇注 ; 电压门控 ; 钾离子通道 ; 频道
  • É parte de: Molecular plant, 2010 (1), p.236-245
  • Notas: 31-2013/Q
    outward rectifier
    channel protein structure
    TP393.08
    Arabidopsis
    gating, K＋-dependent.
    Arabidopsis; K＋ channel; outward rectifier; inward rectifier; channel protein structure; channel protein-cation interaction; gating, K＋-dependent.
    channel protein-cation interaction
    inward rectifier
    K＋ channel
    Q73
  • Descrição: The family of voltage-gated （Shaker-like） potassium channels in plants includes both inward-rectifying （Kin） channels that allow plant cells to accumulate K＋ and outward-rectifying （Kout） channels that mediate K＋ efflux. Despite their dose structural similarities, Kin and Kout channels differ in their gating sensitivity towards voltage and the extracellular K＋ concentration. We have carried out a systematic program of domain swapping between the Kout channel SKOR and the Kin channel KAT1 to examine the impacts on gating of the pore regions, the S4, S5, and the S6 helices. We found that, in particular, the N-terminal part of the S5 played a critical role in KAT1 and SKOR gating. Our findings were supported by molecular dynamics of KAT1 and SKOR homology models. In silico analysis revealed that during channel opening and closing, displacement of certain residues, especially in the S5 and S6 segments, is more pronounced in KAT1 than in SKOR. From our analysis of the S4-S6 region, we conclude that gating （and K＋-
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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