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High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT

Borgen, Tove T. ; Bjørnerem, Åshild ; Solberg, Lene B. ; Andreasen, Camilla ; Brunborg, Cathrine ; Stenbro, May-Britt ; Hübschle, Lars M. ; Froholdt, Anne ; Figved, Wender ; Apalset, Ellen M. ; Gjertsen, Jan-Erik ; Basso, Trude ; Lund, Ida ; Hansen, Ann K. ; Stutzer, Jens-Meinhard ; Dahl, Cecilie ; Omsland, Tone K. ; Nordsletten, Lars ; Frihagen, Frede ; Eriksen, Erik F.

Bone (New York, N.Y.), 2019-05, Vol.122, p.14-21 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT
  • Autor: Borgen, Tove T. ; Bjørnerem, Åshild ; Solberg, Lene B. ; Andreasen, Camilla ; Brunborg, Cathrine ; Stenbro, May-Britt ; Hübschle, Lars M. ; Froholdt, Anne ; Figved, Wender ; Apalset, Ellen M. ; Gjertsen, Jan-Erik ; Basso, Trude ; Lund, Ida ; Hansen, Ann K. ; Stutzer, Jens-Meinhard ; Dahl, Cecilie ; Omsland, Tone K. ; Nordsletten, Lars ; Frihagen, Frede ; Eriksen, Erik F.
  • Assuntos: Bone mineral density ; Epidemiologi medisinsk og odontologisk statistikk: 803 ; Epidemiology medical and dental statistics: 803 ; Fracture risk ; Health sciences: 800 ; Helsefag: 800 ; Medical disciplines: 700 ; Medisinske Fag: 700 ; Osteoporosis ; Trabecular bone score ; VDP ; Vertebral fracture assessment ; Vertebral fractures
  • É parte de: Bone (New York, N.Y.), 2019-05, Vol.122, p.14-21
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Bone
  • Descrição: Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with fragility fractures, their prevalence of vertebral fractures using VFA and prevalence of low TBS, and explore the differences between the sexes and patients with and without vertebral fractures. This cross-sectional sub-study of the Norwegian Capture the Fracture Initiative (NoFRACT) included 839 patients with fragility fractures. Of these, 804 patients had bone mineral density (BMD) of the total hip, femoral neck and/or spine assessed using dual energy x-ray absorptiometry, 679 underwent concomitant VFA, 771 had TBS calculated and 696 responded to a questionnaire. Mean age was 65.8 (SD 8.8) years and 80.5% were women. VFA revealed vertebral fractures in 34.8% of the patients and 34.0% had low TBS (≤ 1.23), with no differences between the sexes. In all patients with valid measures of both VFA and TBS, 53.8% had either vertebral fractures, low TBS, or both. In the patients with osteopenia at the femoral neck, 53.6% had either vertebral fractures, low TBS, or both. Femoral neck BMD T-score ≤ −2.5 was found in 13.8% of all patients, whereas the corresponding figure was 27.4% using the skeletal site with lowest T-score. Women exhibited lower BMD at all sites and lower TBS than men (1.27 vs. 1.29), (all p < 0.05). Patients with prevalent vertebral fractures were older (69.4 vs. 64.0 years), exhibited lower BMD at all sites and lower TBS (1.25 vs.1.29) than those without vertebral fractures (all p < 0.05). Before assessment, 8.2% were taking anti-osteoporotic drugs (AOD), and after assessment, the prescription rate increased to 56.2%. More than half of the patients with fragility fractures had vertebral fractures, low TBS or both. The prescription of AOD increased seven fold from before assessment to after assessment, emphasizing the importance of risk assessment after a fragility fracture. •35% of patients with fragility fracture had prevalent vertebral fractures.•34% of patients with fragility fractures had low trabecular bone score (TBS).•54% of patients had either prevalent vertebral fractures, low TBS or both.•Prescription of anti-osteoporotic drugs increased from 8% before to 56% after assessment.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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