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Biological responses to physicochemical properties of biomaterial surface

Rahmati, Maryam ; Silva, Eduardo A ; Reseland, Janne E ; Heyward, Catherine ; Haugen, Håvard J

Chemical Society reviews, 2020-08, Vol.49 (15), p.5178-5224 [Periódico revisado por pares]

England: Royal Society of Chemistry

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  • Título:
    Biological responses to physicochemical properties of biomaterial surface
  • Autor: Rahmati, Maryam ; Silva, Eduardo A ; Reseland, Janne E ; Heyward, Catherine ; Haugen, Håvard J
  • Assuntos: Animals ; Biochemistry ; Biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - metabolism ; Biological properties ; Biomechanical Phenomena ; Biomedical materials ; Cell Line ; Cells, Cultured ; Chemical engineering ; Chemistry ; Crosstalk ; Diagnostic software ; Diagnostic systems ; Humans ; Implantation ; Metals - chemistry ; Nanostructures - chemistry ; Oxides - chemistry ; Polymers - chemistry ; Porosity ; Principles ; Printing, Three-Dimensional ; Proteins - chemistry ; Signal Transduction ; Signaling ; Surface Properties ; Surgical implants ; Tissue Engineering ; Tissue Scaffolds - chemistry
  • É parte de: Chemical Society reviews, 2020-08, Vol.49 (15), p.5178-5224
  • Notas: Eduardo Silva is an Associate Professor of Biomedical Engineering at the University of California, Davis. Dr Silva obtained his degree in Metallurgical and Materials Science Engineering and PhD in Bioengineering from the University of Porto. Dr Silva has been studying polymeric biomaterials, including alginate and chitosan, for over 15 years. The long-term goal of his current research is to engineer biomaterials for controlled delivery of cells, drugs and/or genes. Dr Silva received several honors and awards, including the Hellman Family Fellow and the Biomaterials Emerging Investigator award. He has 8 patents or patent applications and Novartis recently licensed one of his patents.
    Maryam Rahmati is a PhD Research Fellow in Tissue Regeneration at University of Oslo. She is currently working on the correlation between recently developed chemical and biological imaging techniques for analyzing body responses to biomaterials. She is doing her PhD in Prof. Haugen's research group and her projects are funded by European Training Network within the framework of Horizon2020 Marie Sk odowska-Curie Action (MSCA). She was awarded a master's degree in biomaterials science from Materials and Energy Research Center, Tehran, Iran, 2016. She worked as a biomaterials and tissue engineer at Iran University of Medical Sciences, Tehran, Iran, 2016-2018.
    Catherine A. Heyward completed her MBiochem at Oxford University in 2001, and PhD in lipid signalling under the supervision of Prof. Michael Wakelam at the University of Birmingham in 2006. Since then she has worked on live cell confocal imaging for the study of numerous proteins. She has also trained others in the preparation and imaging of samples at the Institute for Biological Sciences at the University of Oslo. She currently works at the Institute for Clinical Dentistry at the University of Oslo, where she is responsible for histology and imaging of a range of biomaterial samples.
    Dr Janne E. Reseland obtained her PhD in biochemistry from the University of Oslo (UiO) in 1995. She was a postdoc fellow and research scientist at the Faculty of Medicine, UiO, for a period of 8 years. In 2003 Reseland started working on the development of stable extracellular matrices as novel therapeutics for biomimetic induction of hard tissue growth at the Institute for Clinical Dentistry, Faculty of Dentistry, UiO. Reseland became an associate professor in 2005 and a professor in Biomaterials at the Department of Biomaterials in 2007. She is currently (from 2010) the head of the Oral Research Laboratory.
    Professor Haugen is the leader of Biomaterials group, Faculty of Dentistry, University of Oslo. He received his master's degree in chemical engineering from Imperial College, UK, in 2001, and his PhD in biomaterials from Technische Universität München, Germany, in 2004. He worked as a scientist at the Central Institute for Medical Engineering, Munich, Helmholtz Institute for Biomedical Engineering, Aachen and the Tissue Engineering Centre of Imperial College, London. Haugen has been awarded many research grants and innovation awards from both the European Research Council and the Research Council of Norway. Haugen was the past President of the Scandinavian Society for Biomaterials.
    EC/H2020/811226
  • Descrição: Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is devoted to the design and validation of biomaterials, the nature of their interactions with the surrounding biological microenvironment is commonly neglected. This gap of knowledge could be owing to our poor understanding of biochemical signaling pathways, lack of reliable techniques for designing biomaterials with optimal physicochemical properties, and/or poor stability of biomaterial properties after implantation. The success of host responses to biomaterials, known as biocompatibility, depends on chemical principles as the root of both cell signaling pathways in the body and how the biomaterial surface is designed. Most of the current review papers have discussed chemical engineering and biological principles of designing biomaterials as separate topics, which has resulted in neglecting the main role of chemistry in this field. In this review, we discuss biocompatibility in the context of chemistry, what it is and how to assess it, while describing contributions from both biochemical cues and biomaterials as well as the means of harmonizing them. We address both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry. As we aim to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses, we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility complex. Finally, we discuss the progress and challenges associated with the current strategies used for improving the chemical and physical interactions between cells and biomaterial surface. Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes.
  • Editor: England: Royal Society of Chemistry
  • Idioma: Inglês;Norueguês
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