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Are certain diuretics also anticonvulsants?

Hesdorffer, Dale C. ; Stables, James P. ; Hauser, W. Allen ; Annegers, John F. ; Cascino, Gregory

Annals of neurology, 2001-10, Vol.50 (4), p.458-462 [Periódico revisado por pares]

New York: John Wiley & Sons, Inc

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Título:
Are certain diuretics also anticonvulsants?
Autor: Hesdorffer, Dale C. ; Stables, James P. ; Hauser, W. Allen ; Annegers, John F. ; Cascino, Gregory
Assuntos: Aged ; Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Case-Control Studies ; Disease Models, Animal ; Diuretics - therapeutic use ; Dose-Response Relationship, Drug ; Epilepsy - drug therapy ; Female ; Furosemide - therapeutic use ; Humans ; Hydrochlorothiazide - therapeutic use ; Male ; Medical sciences ; Mice ; Mice, Inbred Strains ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Retrospective Studies ; Sodium Chloride Symporter Inhibitors - therapeutic use ; Triamterene - therapeutic use
É parte de: Annals of neurology, 2001-10, Vol.50 (4), p.458-462
Notas: ArticleID:ANA1136
National Institutes of Health - No. AR30582; No. M01RR00645
Epilepsy Foundation of America
ark:/67375/WNG-6Q22WZX0-F
National Institute of Neurologic Diseases and Stroke - No. NS16308
istex:A8C60DD125158F7D1135F94D4F4164D089EEB193
Deceased.
Descrição: A history of diuretic use has been shown to be protective for first unprovoked seizure in adult patients. Recent animal studies suggest that certain diuretics have anticonvulsant activity. We evaluated the potential for the anticonvulsant activity of current diuretic use in a population‐based, case–control study in older adults. We also tested chlorthiazide and furosemide for seizure protection in animal models of epilepsy. Concurrent medical prescription of any diuretic was protective for the development of epilepsy [odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.39–0.99]. A protective effect for current thiazide use was observed (OR = 0.53, CI = 0.31–0.90), and a protective effect for furosemide was suggested (OR = 0.44, CI = 0.1–1.9). In mice, both chlorthiazide and furosemide suppressed the occurrence of maximal electroshock‐induced seizures in a dose‐dependent manner. Chlorthiazide's toxic dose for 50% of animals tested (TD50) could not be achieved even with dosing as high as 1,500 mg/kg; for furosemide, TD50 was 549 mg/kg. Results were similar in rats. Furosemide and chlorthiazide are protective for unprovoked seizures in an epidemiological study and in animal models. Given the potential therapeutic value for seizure control, low toxicity, and low cost, therapeutic efficacy should be explored in clinical studies.
Editor: New York: John Wiley & Sons, Inc
Idioma: Inglês

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Are certain diuretics also anticonvulsants?

Hesdorffer, Dale C. ; Stables, James P. ; Hauser, W. Allen ; Annegers, John F. ; Cascino, Gregory

New York: John Wiley & Sons, Inc

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