Idioma:

Spin trapping of a free radical intermediate formed during microsomal metabolism of hydrazine

Noda, Atsuko ; Noda, Hiroshi ; Ohno, Kohji ; Sendo, Toshiaki ; Misaka, Ayako ; Kanazawa, Yohko ; Isobe, Ryu-ichi ; Hirata, Masaharu

Biochemical and biophysical research communications, 1985-12, Vol.133 (3), p.1086-1091 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Spin trapping of a free radical intermediate formed during microsomal metabolism of hydrazine
Autor: Noda, Atsuko ; Noda, Hiroshi ; Ohno, Kohji ; Sendo, Toshiaki ; Misaka, Ayako ; Kanazawa, Yohko ; Isobe, Ryu-ichi ; Hirata, Masaharu
Assuntos: Animals ; Applied sciences ; Biotransformation ; Catalysis ; Cytochrome P-450 Enzyme System - metabolism ; Electron Spin Resonance Spectroscopy ; Exact sciences and technology ; Free Radicals ; Hydrazines - metabolism ; In Vitro Techniques ; Male ; Mass Spectrometry ; Microsomes, Liver - metabolism ; NADP - physiology ; Other techniques and industries ; Oxidation-Reduction ; Rats ; Rats, Inbred Strains
É parte de: Biochemical and biophysical research communications, 1985-12, Vol.133 (3), p.1086-1091
Descrição: A radical formed during oxidative metabolism of hydrazine in rat liver microsomes was spin-trapped with α-phenyl-t-butylnitrone. The trapped species was identified as hydrazine radical by comparison of its ESR parameters and mass spectrum with those of the adduct formed during CuCl 2 catalyzed oxidation of hydrazine. The requirement for oxygen and NADPH in the microsomal oxidation and the occurrence of a typical binding spectrum by difference spectroscopy suggest the involvement of the participation of the cytochrome P-450 enzyme system in the formation of hydrazine radical which must be a precursor of diimide during microsomal oxidation of hydrazine.
Editor: San Diego, CA: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Spin trapping of a free radical intermediate formed during microsomal metabolism of hydrazine

Noda, Atsuko ; Noda, Hiroshi ; Ohno, Kohji ; Sendo, Toshiaki ; Misaka, Ayako ; Kanazawa, Yohko ; Isobe, Ryu-ichi ; Hirata, Masaharu

San Diego, CA: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.