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New Experimental Models of Skin Homeostasis and Diseases

Larcher, F ; Espada, J ; Díaz-Ley, B ; Jaén, P ; Juarranz, A ; Quintanilla, M

Actas dermo-sifiliográficas (English ed.), 2015-01, Vol.106 (1), p.17-28 [Periódico revisado por pares]

Spain: Elsevier España

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Título:
New Experimental Models of Skin Homeostasis and Diseases
Autor: Larcher, F ; Espada, J ; Díaz-Ley, B ; Jaén, P ; Juarranz, A ; Quintanilla, M
Assuntos: ADN metil transferasa 1 ; Animals ; Biomedical Research ; Células madre epidérmicas ; Dermatology ; Disease Models, Animal ; DNA methyltransferase 1 ; Endoglin ; Endoglina ; Epidermal stem cells ; Equivalentes cutáneos 3D ; Genetically modified mice ; Hair Follicle ; Homeostasis ; Humans ; Internal Medicine ; Mice ; Models, Animal ; Models, Genetic ; Photochemotherapy ; Photodynamic therapy ; Podoplanin ; Podoplanina ; Programa SkinModel-CM ; Ratones con piel humanizada ; Ratones modificados genéticamente ; Skin Diseases - genetics ; Skin Diseases - physiopathology ; Skin Diseases - therapy ; Skin Physiological Phenomena ; Skin-humanized mice ; SkinModel-CM software ; Stem Cells ; Terapia fotodinámica ; Three-dimensional skin equivalents
É parte de: Actas dermo-sifiliográficas (English ed.), 2015-01, Vol.106 (1), p.17-28
Descrição: Abstract Homeostasis, whose regulation at the molecular level is still poorly understood, is intimately related to the functions of epidermal stem cells. Five research groups have been brought together to work on new in vitro and in vivo skin models through the SkinModel-CM program, under the auspices of the Spanish Autonomous Community of Madrid. This project aims to analyze the functions of DNA methyltransferase 1, endoglin, and podoplanin in epidermal stem cell activity, homeostasis, and skin cancer. These new models include 3-dimensional organotypic cultures, immunodeficient skin-humanized mice, and genetically modified mice. Another aim of the program is to use skin-humanized mice to model dermatoses such as Gorlin syndrome and xeroderma pigmentosum in order to optimize new protocols for photodynamic therapy.
Editor: Spain: Elsevier España
Idioma: Inglês

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New Experimental Models of Skin Homeostasis and Diseases

Larcher, F ; Espada, J ; Díaz-Ley, B ; Jaén, P ; Juarranz, A ; Quintanilla, M

Spain: Elsevier España

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