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Does Polyvinyl Alcohol Particle Size Change the Outcome of Prostatic Arterial Embolization for Benign Prostatic Hyperplasia? Results from a Single-Center Randomized Prospective Study

Bilhim, Tiago, MD, PhD ; Pisco, João, MD, PhD ; Campos Pinheiro, Luís, MD, PhD ; Rio Tinto, Hugo, MD ; Fernandes, Lúcia, MD ; Pereira, José A., MD ; Duarte, Marisa, MD ; Oliveira, António G., MD, PhD

Journal of vascular and interventional radiology, 2013-11, Vol.24 (11), p.1595-1602.e1 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Does Polyvinyl Alcohol Particle Size Change the Outcome of Prostatic Arterial Embolization for Benign Prostatic Hyperplasia? Results from a Single-Center Randomized Prospective Study
Autor: Bilhim, Tiago, MD, PhD ; Pisco, João, MD, PhD ; Campos Pinheiro, Luís, MD, PhD ; Rio Tinto, Hugo, MD ; Fernandes, Lúcia, MD ; Pereira, José A., MD ; Duarte, Marisa, MD ; Oliveira, António G., MD, PhD
Assuntos: Aged ; Aged, 80 and over ; Angiography, Digital Subtraction ; Arteries ; Embolization, Therapeutic - adverse effects ; Humans ; Kallikreins - blood ; Male ; Middle Aged ; Pain - diagnosis ; Pain - etiology ; Pain Measurement ; Particle Size ; Polyvinyl Alcohol - administration & dosage ; Polyvinyl Alcohol - adverse effects ; Portugal ; Prospective Studies ; Prostate - blood supply ; Prostate - pathology ; Prostate-Specific Antigen - blood ; Prostatic Hyperplasia - blood ; Prostatic Hyperplasia - diagnosis ; Prostatic Hyperplasia - therapy ; Quality of Life ; Radiography, Interventional ; Radiology ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome
É parte de: Journal of vascular and interventional radiology, 2013-11, Vol.24 (11), p.1595-1602.e1
Descrição: Abstract Purpose To evaluate whether different polyvinyl alcohol (PVA) particle sizes change the outcome of prostatic arterial embolization (PAE) for benign prostatic hyperplasia (BPH). Materials and Methods A randomized prospective study was undertaken in 80 patients (mean age, 63.9 y; range, 48–81 y) with symptomatic BPH undergoing PAE between May and December 2011. Forty patients underwent PAE with 100-µm (group A) and 200-µm PVA particles (group B). Visual analog scales were used to measure pain, and rates of adverse events were recorded. PAE outcomes were evaluated based on International Prostate Symptom Score (IPSS) and quality-of-life (QoL) questionnaires, prostate volume (PV), prostate-specific antigen (PSA) levels, and peak flow rate measurements at baseline and 6 months. Results No differences between groups regarding baseline data, procedural details, or adverse events were noted. Mean pain scores were as follows: during embolization, 3.2 ± 2.97 (group A) versus 2.93 ± 3.28 (group B); after embolization, 0.10 ± 0.50 (group A) versus 0 (group B; P = .20); and the week after PAE, 0.85 ± 1.65 (group A) versus 0.87 ± 1.35 (group B; P = .96). Patients in group B had greater decreases in IPSS (3.64 points; P = .052) and QoL (0.57 points; P = .07). Patients in group A had a greater decrease in PV (8.75 cm3 ; P = .13) and PSA level (2.09 ng/mL; P < .001). Conclusions No significant differences were found in pain scores and adverse events between groups. Whereas PSA level and PV showed greater reductions after PAE with 100-µm PVA particles, clinical outcome was better with 200-µm particles.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Does Polyvinyl Alcohol Particle Size Change the Outcome of Prostatic Arterial Embolization for Benign Prostatic Hyperplasia? Results from a Single-Center Randomized Prospective Study

Bilhim, Tiago, MD, PhD ; Pisco, João, MD, PhD ; Campos Pinheiro, Luís, MD, PhD ; Rio Tinto, Hugo, MD ; Fernandes, Lúcia, MD ; Pereira, José A., MD ; Duarte, Marisa, MD ; Oliveira, António G., MD, PhD

United States: Elsevier Inc

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