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Differentiation Between the Two Types of Amiodarone-Associated Thyrotoxicosis Using Duplex and Amplitude Doppler Sonography

Macedo, T. A. A. ; Chammas, M. C. ; Jorge, P. T. ; Souza, L. P. ; Farage, L. ; Watanabe, T. ; Santos, V. A. ; Cerri, G. G.

Acta radiologica (1987), 2007-05, Vol.48 (4), p.412-421 [Periódico revisado por pares]

London, England: Informa UK Ltd

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Título:
Differentiation Between the Two Types of Amiodarone-Associated Thyrotoxicosis Using Duplex and Amplitude Doppler Sonography
Autor: Macedo, T. A. A. ; Chammas, M. C. ; Jorge, P. T. ; Souza, L. P. ; Farage, L. ; Watanabe, T. ; Santos, V. A. ; Cerri, G. G.
Assuntos: Adult ; Aged ; Aged, 80 and over ; Amiodarone - adverse effects ; Anti-Arrhythmia Agents - adverse effects ; Antiarythmic agents ; Area Under Curve ; Atrial Fibrillation - drug therapy ; Biological and medical sciences ; Blood Flow Velocity - physiology ; Cardiovascular system ; Diagnosis, Differential ; Drug toxicity and drugs side effects treatment ; Endocrinopathies ; Female ; Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted ; Male ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pharmacology. Drug treatments ; Prospective Studies ; Pulsatile Flow - physiology ; ROC Curve ; Thyroid Gland - blood supply ; Thyroid Gland - diagnostic imaging ; Thyroid. Thyroid axis (diseases) ; Thyrotoxicosis - chemically induced ; Thyrotoxicosis - diagnostic imaging ; Ultrasonography, Doppler, Color ; Ultrasonography, Doppler, Duplex ; Vascular Resistance - physiology ; Ventricular Premature Complexes - drug therapy
É parte de: Acta radiologica (1987), 2007-05, Vol.48 (4), p.412-421
Descrição: Purpose: To evaluate the usefulness of Doppler parameters in the differentiation between the two types of amiodarone-associated thyrotoxicosis (AAT). Material and Methods: One hundred thirty-seven individuals were selected at our institution. They were divided into four groups: 84 normal subjects (N), 30 euthyroids taking amiodarone (A), 14 AAT type 1 patients (AAT1), and nine AAT type 2 patients (AAT2). Each AAT type was classified according to 131I uptake and clinical outcome. Blindly, the resistance and pulsatility indexes (RI, PI), systolic peak velocity, and color pixel density (CPD) were calculated. Results: AAT1 had greater CPD than AAT2 (P = 0.02). The latter group had similar vascularization to the N and A groups (P = 0.45). The area under the receiver operating characteristic (ROC) curve showed that systolic peak velocity in the inferior thyroid arteries and CPD were the best parameters in the differentiation between AAT type 1 and AAT type 2 (Az = 0.83 and 0.84, respectively). Impedance indexes were useless. Conclusion: Our results demonstrate that objective tests such as systolic peak velocities in the thyroid arteries and CPD are reliable parameters for differentiating between the two types of AAT.
Editor: London, England: Informa UK Ltd
Idioma: Inglês

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Differentiation Between the Two Types of Amiodarone-Associated Thyrotoxicosis Using Duplex and Amplitude Doppler Sonography

Macedo, T. A. A. ; Chammas, M. C. ; Jorge, P. T. ; Souza, L. P. ; Farage, L. ; Watanabe, T. ; Santos, V. A. ; Cerri, G. G.

London, England: Informa UK Ltd

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