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Phenol-Soluble Modulin α3 Enhances the Human Neutrophil Lysis Mediated by Panton-Valentine Leukocidin

Hongo, Isamu ; Baba, Tadashi ; Oishi, Kanenari ; Morimoto, Yuh ; Ito, Teruyo ; Hiramatsu, Keiichi

The Journal of infectious diseases, 2009-09, Vol.200 (5), p.715-723 [Periódico revisado por pares]

The University of Chicago Press

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  • Título:
    Phenol-Soluble Modulin α3 Enhances the Human Neutrophil Lysis Mediated by Panton-Valentine Leukocidin
  • Autor: Hongo, Isamu ; Baba, Tadashi ; Oishi, Kanenari ; Morimoto, Yuh ; Ito, Teruyo ; Hiramatsu, Keiichi
  • Assuntos: Bacteria ; Cytometry ; Infections ; Leukocidins ; Mice ; Monoclonal antibodies ; Neutrophils ; Room temperature ; Staphylococcus ; Staphylococcus aureus ; Toxins
  • É parte de: The Journal of infectious diseases, 2009-09, Vol.200 (5), p.715-723
  • Notas: istex:B3FDD3058E8CFA087E10EC83122841885980DB1D
    ark:/67375/HXZ-ZG45P26H-V
  • Descrição: Panton-Valentine leukocidin (PVL) has long been considered a critical toxin in severe Staphylococcus aureus infection. PVL presumably breaches the body’s defense system by lysing human polymorphonuclear cells (PMNs). Recently, however, bioactive peptides— phenol-soluble modulins (PSMs)—have been proposed as the main player in the lysis of PMNs, rather than PVL. This study aimed to resolve uncertainty concerning the cause of the lysis of human PMNs by using recombinant PVL toxins and PVL-neutralizing monoclonal antibodies. The recombinant PVL toxins showed strong lytic activity against human but not murine neutrophils. Moreover, the lytic activity of culture supernatants of strains USA400 MW2 and USA300 FPR3757 were completely neutralized by anti-PVL monoclonal antibodies. In contrast, phenol-soluble modulin α3—the most potent PSM peptide—failed to lyse human PMNs at the concentrations contained in the culture supernatants. Phenol-soluble modulin α3 did, however, enhance PVL-mediated lysis of human PMNs
  • Editor: The University of Chicago Press
  • Idioma: Inglês
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