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A click chemistry approach towards nucleic acid major groove functionalization

Andersen, Nicolai K ; Spáčilová, Lucie ; Jensen, Michael D ; Kočalka, Petr ; Jensen, Frank ; Nielsen, Poul

Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.149-150

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Título:
A click chemistry approach towards nucleic acid major groove functionalization
Autor: Andersen, Nicolai K ; Spáčilová, Lucie ; Jensen, Michael D ; Kočalka, Petr ; Jensen, Frank ; Nielsen, Poul
Assuntos: Biochemistry - methods ; DNA - chemistry ; Models, Molecular ; Nucleic Acid Conformation ; Pyrimidine Nucleosides - chemical synthesis ; Pyrimidine Nucleosides - chemistry
É parte de: Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.149-150
Descrição: Abstract A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is precented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.
Editor: England: Oxford University Press
Idioma: Inglês

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