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Social adjustment in depressed patients treated with venlafaxine and amitriptyline

Gorenstein, C ; Andrade, L ; Moreno, R.A ; Artes, R

International clinical psychopharmacology, 2002-07, Vol.17 (4), p.171-175 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

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Título:
Social adjustment in depressed patients treated with venlafaxine and amitriptyline
Autor: Gorenstein, C ; Andrade, L ; Moreno, R.A ; Artes, R
Assuntos: Adult ; Aged ; Amitriptyline - adverse effects ; Amitriptyline - therapeutic use ; Analysis of Variance ; Antidepressive Agents, Second-Generation - adverse effects ; Antidepressive Agents, Second-Generation - therapeutic use ; Antidepressive Agents, Tricyclic - adverse effects ; Antidepressive Agents, Tricyclic - therapeutic use ; Biological and medical sciences ; Cyclohexanols - adverse effects ; Cyclohexanols - therapeutic use ; Depressive Disorder - drug therapy ; Double-Blind Method ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Venlafaxine Hydrochloride
É parte de: International clinical psychopharmacology, 2002-07, Vol.17 (4), p.171-175
Descrição: Social dysfunction is often associated with depressive disorders and its evaluation is an important measure of treatment outcome. The aim of this study was to assess the effect of two treatments, venlafaxine and amitriptyline, on the social functioning of depressed patients. Twenty-eight outpatients, meeting criteria for recurrent or single major depressive episodes, took part in a double-blind, 8-week trial with amitriptyline or venlafaxine (maximum of 150 mg/day) and were assessed by the Self-Report Social Adjustment Scale (SAS-SR) before and at the end of treatment. The scale was also applied to a carefully selected non-psychiatric sample. Both drugs showed the same efficacy on a clinical scale, but venlafaxine improved social functioning more than amitriptyline as only venlafaxine-treated patients reached SAS-SR values estimated for normal subjects. This effect might be linked to the higher rate of side-effects observed with amitriptyline.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins, Inc
Idioma: Inglês

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Social adjustment in depressed patients treated with venlafaxine and amitriptyline

Gorenstein, C ; Andrade, L ; Moreno, R.A ; Artes, R

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

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