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A proton relaxation study of the conformations of some purine mononucleotides in aqueous solution

Geraldes, C. F. G. C ; Santos, H ; Xavier, A. V

Canadian journal of chemistry, 1982-12, Vol.60 (23), p.2976-2983 [Periódico revisado por pares]

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Título:
A proton relaxation study of the conformations of some purine mononucleotides in aqueous solution
Autor: Geraldes, C. F. G. C ; Santos, H ; Xavier, A. V
É parte de: Canadian journal of chemistry, 1982-12, Vol.60 (23), p.2976-2983
Descrição: A method is described by which conformationally averaged interproton distances in mononucleotides are obtained from measured proton spin-lattice relaxation times and published crystal coordinates of selected mononucleotides. The glycosil conformations of adenosine in D 2 O and DMSO-d 6 and of 5′-AMP, 5′-GMP, 3′-AMP, and 2′-AMP in D 2 O are examined by quantitative analysis of the conformationally averaged interproton distances in terms of population distributions obtained from potential energy calculations. 5′-AMP strongly prefers a single glycosyl conformation in the anti range. Besides the anti conformation, 5′-GMP has a secondary minimum in the syn region. 3′-AMP, 2′-AMP, and adenosine have more latitude in their glycosyl torsion angle values, with both the syn and anti regions highly populated.
Editor: Ottawa, Canada: NRC Research Press
Idioma: Inglês;Francês

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