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Progression From Newly Acquired Impaired Fasting Glusose to Type 2 Diabetes

Nichols, Gregory A ; Hillier, Teresa A ; Brown, Jonathan B

Diabetes care, 2007-02, Vol.30 (2), p.228-233 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Progression From Newly Acquired Impaired Fasting Glusose to Type 2 Diabetes
Autor: Nichols, Gregory A ; Hillier, Teresa A ; Brown, Jonathan B
Assuntos: Aged ; Biological and medical sciences ; Blood Glucose - analysis ; Cardiovascular disease ; Clinical medicine ; Comorbidity ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Disease Progression ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fasting ; Female ; Follow-Up Studies ; Glucose Intolerance - complications ; Glucose Intolerance - epidemiology ; Health Maintenance Organizations ; Humans ; Hyperglycemia ; Kidney diseases ; Male ; Medical sciences ; Middle Aged ; Oregon ; Population ; Retrospective Studies ; Studies ; Time Factors ; Variables
É parte de: Diabetes care, 2007-02, Vol.30 (2), p.228-233
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: OBJECTIVE:--We sought to estimate the rate of progression from newly acquired (incident) impaired fasting glucose (IFG) to diabetes under the old and new IFG criteria and to identify predictors of progression to diabetes. RESEARCH DESIGN AND METHODS--We identified 5,452 members of an HMO with no prior history of diabetes, with at least two elevated fasting glucose tests (100-125 mg/dl) measured between 1 January 1994 and 31 December 2003, and with a normal fasting glucose test before the two elevated tests. All data were obtained from electronic records of routine clinical care. Subjects were followed until they developed diabetes, died, left the health plan, or until 31 December 2005. RESULTS:--Overall, 8.1% of subjects whose initial abnormal fasting glucose was 100-109 mg/dl (added IFG subjects) and 24.3% of subjects whose initial abnormal fasting glucose was 110-125 mg/dl (original IFG subjects) developed diabetes (P < 0.0001). Added IFG subjects who progressed to diabetes did so within a mean of 41.4 months, a rate of 1.34% per year. Original IFG subjects converted at a rate of 5.56% per year after an average of 29.0 months. A steeper rate of increasing fasting glucose; higher BMI, blood pressure, and triglycerides; and lower HDL cholesterol predicted diabetes development. CONCLUSIONS:--To our knowledge, these are the first estimates of diabetes incidence from a clinical care setting when the date of IFG onset is approximately known under the new criterion for IFG. The older criterion was more predictive of diabetes development. Many newly identified IFG patients progress to diabetes in <3 years, which is the currently recommended screening interval.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Progression From Newly Acquired Impaired Fasting Glusose to Type 2 Diabetes

Nichols, Gregory A ; Hillier, Teresa A ; Brown, Jonathan B

Alexandria, VA: American Diabetes Association

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