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Osteogenic biphasic calcium sulphate dihydrate/iron-modified α-tricalcium phosphate bone cement for spinal applications: In vivo study

Vlad, M.D. ; Şindilar, E.V. ; Mariñoso, M.L. ; Poeată, I. ; Torres, R. ; López, J. ; Barracó, M. ; Fernández, E.

Acta biomaterialia, 2010-02, Vol.6 (2), p.607-616 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Osteogenic biphasic calcium sulphate dihydrate/iron-modified α-tricalcium phosphate bone cement for spinal applications: In vivo study
Autor: Vlad, M.D. ; Şindilar, E.V. ; Mariñoso, M.L. ; Poeată, I. ; Torres, R. ; López, J. ; Barracó, M. ; Fernández, E.
Assuntos: Animals ; Biocompatible Materials ; Biomaterials ; Bone cement ; Bone Cements ; Calcium phosphate cement ; Calcium Phosphates - administration & dosage ; Calcium Phosphates - chemistry ; Calcium Sulfate - administration & dosage ; Calcium sulphate ; Ciments ossis ; Cirurgia ; Enginyeria biomèdica ; Female ; Fosfat de calci ; Hydroxyapatite ; Iron - chemistry ; Sheep ; Spine - surgery ; Vertebroplasty ; Vèrtebres ; Àrees temàtiques de la UPC ; α-Tricalcium phosphate
É parte de: Acta biomaterialia, 2010-02, Vol.6 (2), p.607-616
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In this study, the biocompatibility and the osteogenic features of a new iron-modified α-tricalcium phosphate (IM/α-TCP) and calcium sulphate dihydrate (CSD) biphasic cement (IM/α-TCP/CSD-BC) have been investigated in terms of the in vivo cement resorption, bone tissue formation and host tissue response on sheep animal model. Histological evaluation performed on undecalcified cement–bone specimens assessed the in vivo behaviour. It has been shown that the new IM/α-TCP/CSD-BC has the ability to produce firm bone binding in vivo (i.e. bioactivity). Qualitative histology proved cement biocompatibility, osteoconduction and favourable resorption, mainly through a macrophage-mediated mechanism. The results showed that the new cements have biocompatible and osteogenic features of interest as possible cancellous bone replacement biomaterial for minimally invasive spinal surgery applications.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Osteogenic biphasic calcium sulphate dihydrate/iron-modified α-tricalcium phosphate bone cement for spinal applications: In vivo study

Vlad, M.D. ; Şindilar, E.V. ; Mariñoso, M.L. ; Poeată, I. ; Torres, R. ; López, J. ; Barracó, M. ; Fernández, E.

England: Elsevier Ltd

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