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Endocannabinoid system and drug addiction: new insights from mutant mice approaches

Maldonado, Rafael ; Robledo, Patricia ; Berrendero, Fernando

Current opinion in neurobiology, 2013-08, Vol.23 (4), p.480-486 [Periódico revisado por pares]

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Título:
Endocannabinoid system and drug addiction: new insights from mutant mice approaches
Autor: Maldonado, Rafael ; Robledo, Patricia ; Berrendero, Fernando
Assuntos: Amidohydrolases - genetics ; Animals ; Cannabinoides ; Disease Models, Animal ; Drogoaddicció ; Endocannabinoids - genetics ; Endocannabinoids - metabolism ; Genètica ; Humans ; Mice ; Mice, Transgenic ; Monoacylglycerol Lipases - genetics ; Mutació (Biologia) ; Mutation - genetics ; Neurology ; Psychiatry ; Receptor, Cannabinoid, CB1 - genetics ; Receptor, Cannabinoid, CB2 - genetics ; Substance-Related Disorders - genetics ; Substance-Related Disorders - metabolism
É parte de: Current opinion in neurobiology, 2013-08, Vol.23 (4), p.480-486
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Descrição: Highlights ► CB1 R plays a crucial role in drug rewarding properties and the motivation to drug-seeking behavior. ► CB2 R modulates cocaine-rewarding properties, although the mechanism involved must be clarified. ► FAAH inhibitors show no abuse liability and may be potential therapeutic agents for drug addiction. ► A genetic tool is now available to study the role of 2-AG without changes in other endocannabinoid elements.
Editor: England: Elsevier Ltd
Idioma: Inglês

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