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Data from: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

Li, Lin ; Jiao, Xiaodong ; D’Atri, Ilaria ; Ono, Fumihito ; Nelson, Ralph ; Chan, Chi-Chao ; Nakaya, Naoki ; Ma, Zhiwei ; Ma, Yan ; Cai, Xiaoying ; Zhang, Longhua ; Lin, Siying ; Hameed, Abdul ; Chioza, Barry A. ; Hardy, Holly ; Arno, Gavin ; Hull, Sarah ; Khan, Muhammad Imran ; Fasham, James ; Harlalka, V. Gaurav ; Michaelides, Michel ; Moore, Anthony T. ; Coban Akdemir, Zeynep Hande ; Jhangiani, Shalini ; Lupski, James R. ; Cremers, Frans P.M. ; Qamar, Raheel ; Salman, Ahmed ; Chilton, John ; Self, Jay ; Ayyagari, Radha ; Kabir, Firoz ; Naeem, Muhammad Asif ; Ali, Muhammad ; Akram, Javed ; Sieving, Paul A. ; Riazuddin, Sheikh ; Baple, Emma L. ; Riazuddin, Sheikh Amer ; Crosby, Andrew H. ; Hejtmancik, J. Fielding ; Cremers, Frans P. M.

Dryad 2019

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Título:
Data from: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa
Autor: Li, Lin ; Jiao, Xiaodong ; D’Atri, Ilaria ; Ono, Fumihito ; Nelson, Ralph ; Chan, Chi-Chao ; Nakaya, Naoki ; Ma, Zhiwei ; Ma, Yan ; Cai, Xiaoying ; Zhang, Longhua ; Lin, Siying ; Hameed, Abdul ; Chioza, Barry A. ; Hardy, Holly ; Arno, Gavin ; Hull, Sarah ; Khan, Muhammad Imran ; Fasham, James ; Harlalka, V. Gaurav ; Michaelides, Michel ; Moore, Anthony T. ; Coban Akdemir, Zeynep Hande ; Jhangiani, Shalini ; Lupski, James R. ; Cremers, Frans P.M. ; Qamar, Raheel ; Salman, Ahmed ; Chilton, John ; Self, Jay ; Ayyagari, Radha ; Kabir, Firoz ; Naeem, Muhammad Asif ; Ali, Muhammad ; Akram, Javed ; Sieving, Paul A. ; Riazuddin, Sheikh ; Baple, Emma L. ; Riazuddin, Sheikh Amer ; Crosby, Andrew H. ; Hejtmancik, J. Fielding ; Cremers, Frans P. M.
Assuntos: chloride channel ; Holocene ; Homo Sapiens ; Retinitis pigmentosa
Notas: 10.1371/journal.pgen.1007504
Raw dataThis submission includes three files:1) WES vcf file for individual 12 of Family 1, 2)WES vcf file for Individual 5 of family 6, and 3) SNP chip data for all individuals shown in figure S2.
RelationTypeNote: IsCitedBy -- 10.1371/journal.pgen.1007504
Descrição: We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride channel highly expressed in the retina, associated with autosomal recessive retinitis pigmentosa (arRP) in eight consanguineous families of Pakistani descent. The p.D25E alteration decreased CLCC1 channel function accompanied by accumulation of mutant protein in granules within the ER lumen, while siRNA knockdown of CLCC1 mRNA induced apoptosis in cultured ARPE-19 cells. TALEN KO in zebrafish was lethal 11 days post fertilization. The depressed electroretinogram (ERG) cone response and cone spectral sensitivity of 5 dpf KO zebrafish and reduced eye size, retinal thickness, and expression of rod and cone opsins could be rescued by injection of wild type CLCC1 mRNA. Clcc1+/- KO mice showed decreased ERGs and photoreceptor number. Together these results strongly suggest that intracellular chloride transport by CLCC1 is a critical process in maintaining retinal integrity, and CLCC1 is crucial for survival and function of retinal cells.
Editor: Dryad
Data de criação/publicação: 2019
Idioma: Inglês

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Data from: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

Dryad 2019

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