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Molecular analysis of translocations associated with Ewing sarcoma: case report

Soares, Leonardo R. ; Bayeh, Hugo A. ; Albuquerque, Izabela Cristina ; Moreira, Marise A. R. ; Coutinho, Miguel A. C. ; Rodrigues, Debora F. ; Queiroz, Paula O. C. ; Ruffo Freitas-Junior

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Título:
Molecular analysis of translocations associated with Ewing sarcoma: case report
Autor: Soares, Leonardo R. ; Bayeh, Hugo A. ; Albuquerque, Izabela Cristina ; Moreira, Marise A. R. ; Coutinho, Miguel A. C. ; Rodrigues, Debora F. ; Queiroz, Paula O. C. ; Ruffo Freitas-Junior
Assuntos: FOS: Medical biotechnology ; Medical Biotechnology not elsewhere classified ; Medicine ; Pathology
Notas: RelationTypeNote: IsSupplementTo -- 10.5935/1676-2444.20190020
10.5935/1676-2444.20190020
Descrição: ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation.
Editor: Figshare
Data de criação/publicação: 2019
Idioma: Inglês

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