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Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study

Diniz, Maria de Fátima Haueisen Sander ; Beleigoli, Alline Maria Rezende ; Schmidt, Maria Inês ; Duncan, Bruce B ; Ribeiro, Antônio Luiz P ; Vidigal, Pedro G ; Benseñor, Isabela M ; Lotufo, Paulo A ; Santos, Itamar S ; Griep, Rosane H ; Barreto, Sandhi Maria

Cadernos de saúde pública, 2020-01, Vol.36 (8), p.e00072120-e00072120 [Periódico revisado por pares]

Brazil: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz

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Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study
Autor: Diniz, Maria de Fátima Haueisen Sander ; Beleigoli, Alline Maria Rezende ; Schmidt, Maria Inês ; Duncan, Bruce B ; Ribeiro, Antônio Luiz P ; Vidigal, Pedro G ; Benseñor, Isabela M ; Lotufo, Paulo A ; Santos, Itamar S ; Griep, Rosane H ; Barreto, Sandhi Maria
Assuntos: Adult ; Body Mass Index ; Brazil - epidemiology ; Cohort Studies ; Homeostasis ; Humans ; Insulin Resistance ; Longitudinal Studies ; Metabolic Syndrome ; Metabolic Syndrome - diagnosis ; Metabolic Syndrome - epidemiology ; Middle Aged ; PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
É parte de: Cadernos de saúde pública, 2020-01, Vol.36 (8), p.e00072120-e00072120
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories.
Editor: Brazil: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
Idioma: Inglês;Português

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Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study

Diniz, Maria de Fátima Haueisen Sander ; Beleigoli, Alline Maria Rezende ; Schmidt, Maria Inês ; Duncan, Bruce B ; Ribeiro, Antônio Luiz P ; Vidigal, Pedro G ; Benseñor, Isabela M ; Lotufo, Paulo A ; Santos, Itamar S ; Griep, Rosane H ; Barreto, Sandhi Maria

Brazil: Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz

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