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Exploring Borate-Modified Calcium Phosphate Ceramics: Antimicrobial Potential and Cytocompatibility Assessment

Fadeeva, Inna V ; Barbaro, Katia ; Altigeri, Annalisa ; Forysenkova, Anna A ; Gafurov, Marat R ; Mamin, Georgy V ; Knot'ko, Alexander V ; Yankova, Viktoriya G ; Zhukova, Anna A ; Russo, Fabrizio ; Rau, Julietta V

Nanomaterials (Basel, Switzerland), 2024-03, Vol.14 (6), p.495 [Revista revisada por pares]

Switzerland: MDPI AG

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Exploring Borate-Modified Calcium Phosphate Ceramics: Antimicrobial Potential and Cytocompatibility Assessment
Autor: Fadeeva, Inna V ; Barbaro, Katia ; Altigeri, Annalisa ; Forysenkova, Anna A ; Gafurov, Marat R ; Mamin, Georgy V ; Knot'ko, Alexander V ; Yankova, Viktoriya G ; Zhukova, Anna A ; Russo, Fabrizio ; Rau, Julietta V
Materias: Adipose tissue ; Anions ; antibacterial ; Antibacterial materials ; Antimicrobial agents ; Aqueous solutions ; Bend strength ; Biocompatibility ; Biological products ; Bone biomaterials ; Bone turnover ; Bones ; borate ; borate doped tricalcium phosphate ; Boron ; Calcium phosphate ; Calcium phosphates ; Cell differentiation ; Ceramics ; Cytotoxicity ; Differentiation (biology) ; Drug dosages ; Drug resistance ; E coli ; Effectiveness ; Electron paramagnetic resonance ; Electron spin resonance ; Gram-positive bacteria ; Hydroxyapatite ; Investigations ; Materials substitution ; Mechanical properties ; Mesenchymal stem cells ; Methicillin ; Microorganisms ; Nitrates ; Pathogens ; Penicillin ; Penicillin G ; Porosity ; Regenerative medicine ; Saline solutions ; Sintering (powder metallurgy) ; Spectroscopy ; Spectrum analysis ; Staphylococcus infections ; Stem cells ; Substitute bone ; Tissue engineering ; Transplants & implants ; Tricalcium phosphate ; X-ray diffraction
Es parte de: Nanomaterials (Basel, Switzerland), 2024-03, Vol.14 (6), p.495
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descripción: Addressing periprosthetic infections, which present significant healing challenges that often require revision surgeries, necessitates the development of novel antibacterial materials and implants. Current research focuses on creating materials that hinder bacterial adhesion, colonization, and proliferation in surrounding tissues. Boron (B)-containing compounds are known for their antibacterial properties and potential in bone metabolism for regenerative medicine. In this study, we synthesized B-containing tricalcium phosphate (0.3B-TCP) with 1.1 wt.% B content via precipitation from aqueous solutions and sintering at 1100 °C. X-ray diffraction confirmed the ceramic's primary crystalline phase as β-TCP, with B evenly distributed according to energy-dispersive spectroscopy data. Electron paramagnetic resonance (EPR) data verified stable paramagnetic borate anions, indicating successful BO substitution for phosphate groups. The microstructural properties of 0.3B-TCP ceramic were assessed before and after soaking in a saline solution. Its bending strength was approximately 30 MPa, and its porosity was about 33%. 0.3B-TCP ceramic demonstrated significant antimicrobial efficacy against various bacterial strains and a fungus. Cytotoxicity evaluation using equine adipose tissue-derived mesenchymal stem cells and osteogenic differentiation assessment were conducted. The combination of antibacterial efficacy and good cytocompatibility suggests 0.3B-TCP ceramic as a promising bone substitute material.
Editor: Switzerland: MDPI AG
Idioma: Inglés

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Exploring Borate-Modified Calcium Phosphate Ceramics: Antimicrobial Potential and Cytocompatibility Assessment

Fadeeva, Inna V ; Barbaro, Katia ; Altigeri, Annalisa ; Forysenkova, Anna A ; Gafurov, Marat R ; Mamin, Georgy V ; Knot'ko, Alexander V ; Yankova, Viktoriya G ; Zhukova, Anna A ; Russo, Fabrizio ; Rau, Julietta V

Switzerland: MDPI AG

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