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A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular self-assemblies

Paolantoni, Delphine ; Cantel, Sonia ; Dumy, Pascal ; Ulrich, Sébastien

International journal of molecular sciences, 2015-02, Vol.16 (2), p.3609-3625 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular self-assemblies
Autor: Paolantoni, Delphine ; Cantel, Sonia ; Dumy, Pascal ; Ulrich, Sébastien
Assuntos: Amination ; Biochemistry ; Combinatorial Chemistry Techniques - methods ; Deoxyribonucleic acid ; DNA ; DNA, Single-Stranded - chemistry ; DNA-templated self-assembly ; dynamic combinatorial chemistry ; dynamic covalent chemistry ; Guanidine - chemistry ; Life Sciences ; Models, Molecular ; Molecular biology ; Molecular Structure ; Organometallic Compounds - chemistry ; supramolecular interactions
É parte de: International journal of molecular sciences, 2015-02, Vol.16 (2), p.3609-3625
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC4346916
Descrição: DNA-templated self-assembly is an emerging strategy for generating functional supramolecular systems, which requires the identification of potent multi-point binding ligands. In this line, we recently showed that bis-functionalized guanidinium compounds can interact with ssDNA and generate a supramolecular complex through the recognition of the phosphodiester backbone of DNA. In order to probe the importance of secondary interactions and to identify side groups that stabilize these DNA-templated self-assemblies, we report herein the implementation of a dynamic combinatorial approach. We used an in situ fragment assembly process based on reductive amination and tested various side groups, including amino acids. The results reveal that aromatic and cationic side groups participate in secondary supramolecular interactions that stabilize the complexes formed with ssDNA.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular self-assemblies

Paolantoni, Delphine ; Cantel, Sonia ; Dumy, Pascal ; Ulrich, Sébastien

Switzerland: MDPI AG

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